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Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study
The protective effect of dental scaling in Parkinson’s disease (PD) remains inconclusive. The aim of this study was to analyze the association between dental scaling and the development of PD. A retrospective nested case-control study was performed using the National Health Insurance Research Databa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121362/ https://www.ncbi.nlm.nih.gov/pubmed/30049978 http://dx.doi.org/10.3390/ijerph15081587 |
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author | Chen, Chang-Kai Huang, Jing-Yang Wu, Yung-Tsan Chang, Yu-Chao |
author_facet | Chen, Chang-Kai Huang, Jing-Yang Wu, Yung-Tsan Chang, Yu-Chao |
author_sort | Chen, Chang-Kai |
collection | PubMed |
description | The protective effect of dental scaling in Parkinson’s disease (PD) remains inconclusive. The aim of this study was to analyze the association between dental scaling and the development of PD. A retrospective nested case-control study was performed using the National Health Insurance Research Database of Taiwan. The authors identified 4765 patients with newly diagnosed PD from 2005 to 2013 and 19,060 individuals without PD by matching sex, age, and index year. In subgroup 1, with individuals aged 40–69 years, individuals without periodontal inflammatory disease (PID) showed a protective effect of dental scaling against PD development, especially for dental scaling over five consecutive years (adjusted odds ratio = 0.204, 95% CI = 0.047–0.886, p = 0.0399). In general, the protective effect of dental scaling showed greater benefit for individuals with PID than for those without PID, regardless of whether dental scaling was performed for five consecutive years. In subgroup 2, with patients aged ≥70 years, the discontinued (not five consecutive years) scaling showed increased risk of PD. This was the first study to show that patients without PID who underwent dental scaling over five consecutive years had a significantly lower risk of developing PD. These findings emphasize the value of early and consecutive dental scaling to prevent the development of PD. |
format | Online Article Text |
id | pubmed-6121362 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61213622018-09-07 Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study Chen, Chang-Kai Huang, Jing-Yang Wu, Yung-Tsan Chang, Yu-Chao Int J Environ Res Public Health Article The protective effect of dental scaling in Parkinson’s disease (PD) remains inconclusive. The aim of this study was to analyze the association between dental scaling and the development of PD. A retrospective nested case-control study was performed using the National Health Insurance Research Database of Taiwan. The authors identified 4765 patients with newly diagnosed PD from 2005 to 2013 and 19,060 individuals without PD by matching sex, age, and index year. In subgroup 1, with individuals aged 40–69 years, individuals without periodontal inflammatory disease (PID) showed a protective effect of dental scaling against PD development, especially for dental scaling over five consecutive years (adjusted odds ratio = 0.204, 95% CI = 0.047–0.886, p = 0.0399). In general, the protective effect of dental scaling showed greater benefit for individuals with PID than for those without PID, regardless of whether dental scaling was performed for five consecutive years. In subgroup 2, with patients aged ≥70 years, the discontinued (not five consecutive years) scaling showed increased risk of PD. This was the first study to show that patients without PID who underwent dental scaling over five consecutive years had a significantly lower risk of developing PD. These findings emphasize the value of early and consecutive dental scaling to prevent the development of PD. MDPI 2018-07-26 2018-08 /pmc/articles/PMC6121362/ /pubmed/30049978 http://dx.doi.org/10.3390/ijerph15081587 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Chang-Kai Huang, Jing-Yang Wu, Yung-Tsan Chang, Yu-Chao Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study |
title | Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study |
title_full | Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study |
title_fullStr | Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study |
title_full_unstemmed | Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study |
title_short | Dental Scaling Decreases the Risk of Parkinson’s Disease: A Nationwide Population-Based Nested Case-Control Study |
title_sort | dental scaling decreases the risk of parkinson’s disease: a nationwide population-based nested case-control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121362/ https://www.ncbi.nlm.nih.gov/pubmed/30049978 http://dx.doi.org/10.3390/ijerph15081587 |
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