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Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells
After birth, the development of hematopoietic cells occurs in the bone marrow. Hematopoietic differentiation is finely tuned by cell-intrinsic mechanisms and lineage-specific transcription factors. However, it is now clear that the bone marrow microenvironment plays an essential role in the maintena...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121419/ https://www.ncbi.nlm.nih.gov/pubmed/30103411 http://dx.doi.org/10.3390/ijms19082353 |
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author | Aurrand-Lions, Michel Mancini, Stéphane J. C. |
author_facet | Aurrand-Lions, Michel Mancini, Stéphane J. C. |
author_sort | Aurrand-Lions, Michel |
collection | PubMed |
description | After birth, the development of hematopoietic cells occurs in the bone marrow. Hematopoietic differentiation is finely tuned by cell-intrinsic mechanisms and lineage-specific transcription factors. However, it is now clear that the bone marrow microenvironment plays an essential role in the maintenance of hematopoietic stem cells (HSC) and their differentiation into more mature lineages. Mesenchymal and endothelial cells contribute to a protective microenvironment called hematopoietic niches that secrete specific factors and establish a direct contact with developing hematopoietic cells. A number of recent studies have addressed in mouse models the specific molecular events that are involved in the cellular crosstalk between hematopoietic subsets and their niches. This has led to the concept that hematopoietic differentiation and commitment towards a given hematopoietic pathway is a dynamic process controlled at least partially by the bone marrow microenvironment. In this review, we discuss the evolving view of murine hematopoietic–stromal cell crosstalk that is involved in HSC maintenance and commitment towards B cell differentiation. |
format | Online Article Text |
id | pubmed-6121419 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61214192018-09-07 Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells Aurrand-Lions, Michel Mancini, Stéphane J. C. Int J Mol Sci Review After birth, the development of hematopoietic cells occurs in the bone marrow. Hematopoietic differentiation is finely tuned by cell-intrinsic mechanisms and lineage-specific transcription factors. However, it is now clear that the bone marrow microenvironment plays an essential role in the maintenance of hematopoietic stem cells (HSC) and their differentiation into more mature lineages. Mesenchymal and endothelial cells contribute to a protective microenvironment called hematopoietic niches that secrete specific factors and establish a direct contact with developing hematopoietic cells. A number of recent studies have addressed in mouse models the specific molecular events that are involved in the cellular crosstalk between hematopoietic subsets and their niches. This has led to the concept that hematopoietic differentiation and commitment towards a given hematopoietic pathway is a dynamic process controlled at least partially by the bone marrow microenvironment. In this review, we discuss the evolving view of murine hematopoietic–stromal cell crosstalk that is involved in HSC maintenance and commitment towards B cell differentiation. MDPI 2018-08-10 /pmc/articles/PMC6121419/ /pubmed/30103411 http://dx.doi.org/10.3390/ijms19082353 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Aurrand-Lions, Michel Mancini, Stéphane J. C. Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells |
title | Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells |
title_full | Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells |
title_fullStr | Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells |
title_full_unstemmed | Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells |
title_short | Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells |
title_sort | murine bone marrow niches from hematopoietic stem cells to b cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121419/ https://www.ncbi.nlm.nih.gov/pubmed/30103411 http://dx.doi.org/10.3390/ijms19082353 |
work_keys_str_mv | AT aurrandlionsmichel murinebonemarrownichesfromhematopoieticstemcellstobcells AT mancinistephanejc murinebonemarrownichesfromhematopoieticstemcellstobcells |