Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance

Trans-ferulic acid-4-β-glucoside (C(16)H(20)O(9), TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice...

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Detalles Bibliográficos
Autores principales: Xue, Chong, Lu, Huanyu, Liu, Ying, Zhang, Jianbin, Wang, Jiye, Luo, Wenjing, Zhang, Wenbin, Chen, Jingyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121433/
https://www.ncbi.nlm.nih.gov/pubmed/30096768
http://dx.doi.org/10.3390/ijms19082321
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author Xue, Chong
Lu, Huanyu
Liu, Ying
Zhang, Jianbin
Wang, Jiye
Luo, Wenjing
Zhang, Wenbin
Chen, Jingyuan
author_facet Xue, Chong
Lu, Huanyu
Liu, Ying
Zhang, Jianbin
Wang, Jiye
Luo, Wenjing
Zhang, Wenbin
Chen, Jingyuan
author_sort Xue, Chong
collection PubMed
description Trans-ferulic acid-4-β-glucoside (C(16)H(20)O(9), TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury.
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spelling pubmed-61214332018-09-07 Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance Xue, Chong Lu, Huanyu Liu, Ying Zhang, Jianbin Wang, Jiye Luo, Wenjing Zhang, Wenbin Chen, Jingyuan Int J Mol Sci Article Trans-ferulic acid-4-β-glucoside (C(16)H(20)O(9), TFA-4β-G) is a monomer extracted from the Chinese medicine called radix aconiti carmichaeli (Fuzi). To date, research on this substance is lacking. Here, we found that trans-ferulic acid-4-β-glucoside effectively promoted cold acclimatization in mice via increased heat production and alleviation of oxidative stress in a cold environment. Thus, our work indicates that ferulic acid-4-β-glucoside is a potential therapeutic candidate for prevention and treatment of cold stress injury. MDPI 2018-08-08 /pmc/articles/PMC6121433/ /pubmed/30096768 http://dx.doi.org/10.3390/ijms19082321 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xue, Chong
Lu, Huanyu
Liu, Ying
Zhang, Jianbin
Wang, Jiye
Luo, Wenjing
Zhang, Wenbin
Chen, Jingyuan
Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance
title Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance
title_full Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance
title_fullStr Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance
title_full_unstemmed Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance
title_short Trans-Ferulic Acid-4-β-Glucoside Alleviates Cold-Induced Oxidative Stress and Promotes Cold Tolerance
title_sort trans-ferulic acid-4-β-glucoside alleviates cold-induced oxidative stress and promotes cold tolerance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121433/
https://www.ncbi.nlm.nih.gov/pubmed/30096768
http://dx.doi.org/10.3390/ijms19082321
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