Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment

Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeo...

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Autores principales: Kasembeli, Moses M., Bharadwaj, Uddalak, Robinson, Prema, Tweardy, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121470/
https://www.ncbi.nlm.nih.gov/pubmed/30081609
http://dx.doi.org/10.3390/ijms19082299
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author Kasembeli, Moses M.
Bharadwaj, Uddalak
Robinson, Prema
Tweardy, David J.
author_facet Kasembeli, Moses M.
Bharadwaj, Uddalak
Robinson, Prema
Tweardy, David J.
author_sort Kasembeli, Moses M.
collection PubMed
description Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need.
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spelling pubmed-61214702018-09-07 Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment Kasembeli, Moses M. Bharadwaj, Uddalak Robinson, Prema Tweardy, David J. Int J Mol Sci Review Signal transducer and activator of transcription (STAT) 3 plays a central role in the host response to injury. It is activated rapidly within cells by many cytokines, most notably those in the IL-6 family, leading to pro-proliferative and pro-survival programs that assist the host in regaining homeostasis. With persistent activation, however, chronic inflammation and fibrosis ensue, leading to a number of debilitating diseases. This review summarizes advances in our understanding of the role of STAT3 and its targeting in diseases marked by chronic inflammation and/or fibrosis with a focus on those with the largest unmet medical need. MDPI 2018-08-05 /pmc/articles/PMC6121470/ /pubmed/30081609 http://dx.doi.org/10.3390/ijms19082299 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kasembeli, Moses M.
Bharadwaj, Uddalak
Robinson, Prema
Tweardy, David J.
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
title Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
title_full Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
title_fullStr Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
title_full_unstemmed Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
title_short Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
title_sort contribution of stat3 to inflammatory and fibrotic diseases and prospects for its targeting for treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121470/
https://www.ncbi.nlm.nih.gov/pubmed/30081609
http://dx.doi.org/10.3390/ijms19082299
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