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Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influe...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121494/ https://www.ncbi.nlm.nih.gov/pubmed/30060580 http://dx.doi.org/10.3390/ijms19082210 |
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author | Duszka, Kalina Wahli, Walter |
author_facet | Duszka, Kalina Wahli, Walter |
author_sort | Duszka, Kalina |
collection | PubMed |
description | Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota–gut–brain axis. |
format | Online Article Text |
id | pubmed-6121494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-61214942018-09-07 Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors Duszka, Kalina Wahli, Walter Int J Mol Sci Review Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota–gut–brain axis. MDPI 2018-07-28 /pmc/articles/PMC6121494/ /pubmed/30060580 http://dx.doi.org/10.3390/ijms19082210 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Duszka, Kalina Wahli, Walter Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors |
title | Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors |
title_full | Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors |
title_fullStr | Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors |
title_full_unstemmed | Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors |
title_short | Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors |
title_sort | enteric microbiota–gut–brain axis from the perspective of nuclear receptors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121494/ https://www.ncbi.nlm.nih.gov/pubmed/30060580 http://dx.doi.org/10.3390/ijms19082210 |
work_keys_str_mv | AT duszkakalina entericmicrobiotagutbrainaxisfromtheperspectiveofnuclearreceptors AT wahliwalter entericmicrobiotagutbrainaxisfromtheperspectiveofnuclearreceptors |