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Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors

Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influe...

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Autores principales: Duszka, Kalina, Wahli, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121494/
https://www.ncbi.nlm.nih.gov/pubmed/30060580
http://dx.doi.org/10.3390/ijms19082210
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author Duszka, Kalina
Wahli, Walter
author_facet Duszka, Kalina
Wahli, Walter
author_sort Duszka, Kalina
collection PubMed
description Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota–gut–brain axis.
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spelling pubmed-61214942018-09-07 Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors Duszka, Kalina Wahli, Walter Int J Mol Sci Review Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota–gut–brain axis. MDPI 2018-07-28 /pmc/articles/PMC6121494/ /pubmed/30060580 http://dx.doi.org/10.3390/ijms19082210 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Duszka, Kalina
Wahli, Walter
Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_full Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_fullStr Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_full_unstemmed Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_short Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_sort enteric microbiota–gut–brain axis from the perspective of nuclear receptors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121494/
https://www.ncbi.nlm.nih.gov/pubmed/30060580
http://dx.doi.org/10.3390/ijms19082210
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