Retinoid X Receptor Antagonists

Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a b...

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Detalles Bibliográficos
Autores principales: Watanabe, Masaki, Kakuta, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121510/
https://www.ncbi.nlm.nih.gov/pubmed/30103423
http://dx.doi.org/10.3390/ijms19082354
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author Watanabe, Masaki
Kakuta, Hiroki
author_facet Watanabe, Masaki
Kakuta, Hiroki
author_sort Watanabe, Masaki
collection PubMed
description Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.
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spelling pubmed-61215102018-09-07 Retinoid X Receptor Antagonists Watanabe, Masaki Kakuta, Hiroki Int J Mol Sci Review Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research. MDPI 2018-08-10 /pmc/articles/PMC6121510/ /pubmed/30103423 http://dx.doi.org/10.3390/ijms19082354 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Watanabe, Masaki
Kakuta, Hiroki
Retinoid X Receptor Antagonists
title Retinoid X Receptor Antagonists
title_full Retinoid X Receptor Antagonists
title_fullStr Retinoid X Receptor Antagonists
title_full_unstemmed Retinoid X Receptor Antagonists
title_short Retinoid X Receptor Antagonists
title_sort retinoid x receptor antagonists
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121510/
https://www.ncbi.nlm.nih.gov/pubmed/30103423
http://dx.doi.org/10.3390/ijms19082354
work_keys_str_mv AT watanabemasaki retinoidxreceptorantagonists
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