Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?

Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence...

Descripción completa

Detalles Bibliográficos
Autores principales: Nitti, Mariapaola, Piras, Sabrina, Brondolo, Lorenzo, Marinari, Umberto Maria, Pronzato, Maria Adelaide, Furfaro, Anna Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121636/
https://www.ncbi.nlm.nih.gov/pubmed/30071692
http://dx.doi.org/10.3390/ijms19082260
_version_ 1783352514687533056
author Nitti, Mariapaola
Piras, Sabrina
Brondolo, Lorenzo
Marinari, Umberto Maria
Pronzato, Maria Adelaide
Furfaro, Anna Lisa
author_facet Nitti, Mariapaola
Piras, Sabrina
Brondolo, Lorenzo
Marinari, Umberto Maria
Pronzato, Maria Adelaide
Furfaro, Anna Lisa
author_sort Nitti, Mariapaola
collection PubMed
description Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence have highlighted that HO-1 expression is associated to neuronal damage and neurodegeneration especially in Alzheimer’s and Parkinson’s diseases. In this review, we summarize the current literature regarding the role of HO-1 in nervous system pointing out different molecular mechanisms possibly responsible for HO-1 up-regulation in nervous system homeostasis and neurodegeneration.
format Online
Article
Text
id pubmed-6121636
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-61216362018-09-07 Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration? Nitti, Mariapaola Piras, Sabrina Brondolo, Lorenzo Marinari, Umberto Maria Pronzato, Maria Adelaide Furfaro, Anna Lisa Int J Mol Sci Review Heme oxygenase 1 (HO-1) up-regulation is recognized as a pivotal mechanism of cell adaptation to stress. Under control of different transcription factors but with a prominent role played by Nrf2, HO-1 induction is crucial also in nervous system response to damage. However, several lines of evidence have highlighted that HO-1 expression is associated to neuronal damage and neurodegeneration especially in Alzheimer’s and Parkinson’s diseases. In this review, we summarize the current literature regarding the role of HO-1 in nervous system pointing out different molecular mechanisms possibly responsible for HO-1 up-regulation in nervous system homeostasis and neurodegeneration. MDPI 2018-08-01 /pmc/articles/PMC6121636/ /pubmed/30071692 http://dx.doi.org/10.3390/ijms19082260 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nitti, Mariapaola
Piras, Sabrina
Brondolo, Lorenzo
Marinari, Umberto Maria
Pronzato, Maria Adelaide
Furfaro, Anna Lisa
Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
title Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
title_full Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
title_fullStr Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
title_full_unstemmed Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
title_short Heme Oxygenase 1 in the Nervous System: Does It Favor Neuronal Cell Survival or Induce Neurodegeneration?
title_sort heme oxygenase 1 in the nervous system: does it favor neuronal cell survival or induce neurodegeneration?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121636/
https://www.ncbi.nlm.nih.gov/pubmed/30071692
http://dx.doi.org/10.3390/ijms19082260
work_keys_str_mv AT nittimariapaola hemeoxygenase1inthenervoussystemdoesitfavorneuronalcellsurvivalorinduceneurodegeneration
AT pirassabrina hemeoxygenase1inthenervoussystemdoesitfavorneuronalcellsurvivalorinduceneurodegeneration
AT brondololorenzo hemeoxygenase1inthenervoussystemdoesitfavorneuronalcellsurvivalorinduceneurodegeneration
AT marinariumbertomaria hemeoxygenase1inthenervoussystemdoesitfavorneuronalcellsurvivalorinduceneurodegeneration
AT pronzatomariaadelaide hemeoxygenase1inthenervoussystemdoesitfavorneuronalcellsurvivalorinduceneurodegeneration
AT furfaroannalisa hemeoxygenase1inthenervoussystemdoesitfavorneuronalcellsurvivalorinduceneurodegeneration

Ejemplares similares