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The Protein Phosphatase PPM1G Destabilizes HIF-1α Expression

Hypoxia-inducible factors (HIFs) are key regulators of hypoxic responses, and their stability and transcriptional activity are controlled by several kinases. However, the regulation of HIF by protein phosphatases has not been thoroughly investigated. Here, we found that overexpression of Mg(2+)/Mn(2...

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Detalles Bibliográficos
Autores principales: Pyo, Jaehyuk, Ryu, Jaewook, Kim, Wootae, Choi, Jae-Sun, Jeong, Joo-Won, Kim, Ja-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121667/
https://www.ncbi.nlm.nih.gov/pubmed/30081604
http://dx.doi.org/10.3390/ijms19082297