Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications

Biological tissues can automatically repair themselves after damage. Examples include skin, muscle, soft tissue, etc. Inspired by these living tissues, numerous self-healing hydrogels have been developed recently. Chitosan-based self-healing hydrogels constructed via dynamic imine bonds have been wi...

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Detalles Bibliográficos
Autores principales: Xu, Yanshuang, Li, Yongsan, Chen, Qiaomei, Fu, Lihua, Tao, Lei, Wei, Yen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121669/
https://www.ncbi.nlm.nih.gov/pubmed/30060504
http://dx.doi.org/10.3390/ijms19082198
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author Xu, Yanshuang
Li, Yongsan
Chen, Qiaomei
Fu, Lihua
Tao, Lei
Wei, Yen
author_facet Xu, Yanshuang
Li, Yongsan
Chen, Qiaomei
Fu, Lihua
Tao, Lei
Wei, Yen
author_sort Xu, Yanshuang
collection PubMed
description Biological tissues can automatically repair themselves after damage. Examples include skin, muscle, soft tissue, etc. Inspired by these living tissues, numerous self-healing hydrogels have been developed recently. Chitosan-based self-healing hydrogels constructed via dynamic imine bonds have been widely studied due to their simple preparation, good biocompatibility, and automatic reparability under physiological conditions. In this mini-review, we highlighted chitosan-based self-healing hydrogels based on dynamic imine chemistry, and provided an overview of the preparation of these hydrogels and their bioapplications in cell therapy, tumor therapy, and wound healing.
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spelling pubmed-61216692018-09-07 Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications Xu, Yanshuang Li, Yongsan Chen, Qiaomei Fu, Lihua Tao, Lei Wei, Yen Int J Mol Sci Review Biological tissues can automatically repair themselves after damage. Examples include skin, muscle, soft tissue, etc. Inspired by these living tissues, numerous self-healing hydrogels have been developed recently. Chitosan-based self-healing hydrogels constructed via dynamic imine bonds have been widely studied due to their simple preparation, good biocompatibility, and automatic reparability under physiological conditions. In this mini-review, we highlighted chitosan-based self-healing hydrogels based on dynamic imine chemistry, and provided an overview of the preparation of these hydrogels and their bioapplications in cell therapy, tumor therapy, and wound healing. MDPI 2018-07-27 /pmc/articles/PMC6121669/ /pubmed/30060504 http://dx.doi.org/10.3390/ijms19082198 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xu, Yanshuang
Li, Yongsan
Chen, Qiaomei
Fu, Lihua
Tao, Lei
Wei, Yen
Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications
title Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications
title_full Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications
title_fullStr Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications
title_full_unstemmed Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications
title_short Injectable and Self-Healing Chitosan Hydrogel Based on Imine Bonds: Design and Therapeutic Applications
title_sort injectable and self-healing chitosan hydrogel based on imine bonds: design and therapeutic applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121669/
https://www.ncbi.nlm.nih.gov/pubmed/30060504
http://dx.doi.org/10.3390/ijms19082198
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