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Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals

The motor thalamus (MTh) and the nucleus reticularis thalami (NRT) have been largely neglected in Parkinson's disease (PD) research, despite their key role as interface between basal ganglia (BG) and cortex (Cx). In the present study, we investigated the oscillatory activity within the Cx, MTh,...

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Autores principales: Grandi, Laura C., Kaelin-Lang, Alain, Orban, Gergely, Song, Wei, Salvadè, Agnese, Stefani, Alessandro, Di Giovanni, Giuseppe, Galati, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122290/
https://www.ncbi.nlm.nih.gov/pubmed/30210425
http://dx.doi.org/10.3389/fneur.2018.00663
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author Grandi, Laura C.
Kaelin-Lang, Alain
Orban, Gergely
Song, Wei
Salvadè, Agnese
Stefani, Alessandro
Di Giovanni, Giuseppe
Galati, Salvatore
author_facet Grandi, Laura C.
Kaelin-Lang, Alain
Orban, Gergely
Song, Wei
Salvadè, Agnese
Stefani, Alessandro
Di Giovanni, Giuseppe
Galati, Salvatore
author_sort Grandi, Laura C.
collection PubMed
description The motor thalamus (MTh) and the nucleus reticularis thalami (NRT) have been largely neglected in Parkinson's disease (PD) research, despite their key role as interface between basal ganglia (BG) and cortex (Cx). In the present study, we investigated the oscillatory activity within the Cx, MTh, and NRT, in normal and different dopamine (DA)-deficient states. We performed our experiments in both acute and chronic DA-denervated rats by injecting into the medial forebrain bundle (MFB) tetrodotoxin (TTX) or 6-hydroxydopamine (6-OHDA), respectively. Interestingly, almost all the electroencephalogram (EEG) frequency bands changed in acute and/or chronic DA depletion, suggesting alteration of all oscillatory activities and not of a specific band. Overall, δ (2–4 Hz) and θ (4–8 Hz) band decreased in NRT and Cx in acute and chronic state, whilst, α (8–13 Hz) band decreased in acute and chronic states in the MTh and NRT but not in the Cx. The β (13–40 Hz) and γ (60–90 Hz) bands were enhanced in the Cx. In the NRT the β bands decreased, except for high-β (Hβ, 25–30 Hz) that increased in acute state. In the MTh, Lβ and Hβ decreased in acute DA depletion state and γ decreased in both TTX and 6-OHDA-treated animals. These results confirm that abnormal cortical β band are present in the established DA deficiency and it might be considered a hallmark of PD. The abnormal oscillatory activity in frequency interval of other bands, in particular the dampening of low frequencies in thalamic stations, in both states of DA depletion might also underlie PD motor and non-motor symptoms. Our data highlighted the effects of acute depletion of DA and the strict interplay in the oscillatory activity between the MTh and NRT in both acute and chronic stage of DA depletion. Moreover, our findings emphasize early alterations in the NRT, a crucial station for thalamic information processing.
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spelling pubmed-61222902018-09-12 Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals Grandi, Laura C. Kaelin-Lang, Alain Orban, Gergely Song, Wei Salvadè, Agnese Stefani, Alessandro Di Giovanni, Giuseppe Galati, Salvatore Front Neurol Neurology The motor thalamus (MTh) and the nucleus reticularis thalami (NRT) have been largely neglected in Parkinson's disease (PD) research, despite their key role as interface between basal ganglia (BG) and cortex (Cx). In the present study, we investigated the oscillatory activity within the Cx, MTh, and NRT, in normal and different dopamine (DA)-deficient states. We performed our experiments in both acute and chronic DA-denervated rats by injecting into the medial forebrain bundle (MFB) tetrodotoxin (TTX) or 6-hydroxydopamine (6-OHDA), respectively. Interestingly, almost all the electroencephalogram (EEG) frequency bands changed in acute and/or chronic DA depletion, suggesting alteration of all oscillatory activities and not of a specific band. Overall, δ (2–4 Hz) and θ (4–8 Hz) band decreased in NRT and Cx in acute and chronic state, whilst, α (8–13 Hz) band decreased in acute and chronic states in the MTh and NRT but not in the Cx. The β (13–40 Hz) and γ (60–90 Hz) bands were enhanced in the Cx. In the NRT the β bands decreased, except for high-β (Hβ, 25–30 Hz) that increased in acute state. In the MTh, Lβ and Hβ decreased in acute DA depletion state and γ decreased in both TTX and 6-OHDA-treated animals. These results confirm that abnormal cortical β band are present in the established DA deficiency and it might be considered a hallmark of PD. The abnormal oscillatory activity in frequency interval of other bands, in particular the dampening of low frequencies in thalamic stations, in both states of DA depletion might also underlie PD motor and non-motor symptoms. Our data highlighted the effects of acute depletion of DA and the strict interplay in the oscillatory activity between the MTh and NRT in both acute and chronic stage of DA depletion. Moreover, our findings emphasize early alterations in the NRT, a crucial station for thalamic information processing. Frontiers Media S.A. 2018-08-28 /pmc/articles/PMC6122290/ /pubmed/30210425 http://dx.doi.org/10.3389/fneur.2018.00663 Text en Copyright © 2018 Grandi, Kaelin-Lang, Orban, Song, Salvadè, Stefani, Di Giovanni and Galati. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Grandi, Laura C.
Kaelin-Lang, Alain
Orban, Gergely
Song, Wei
Salvadè, Agnese
Stefani, Alessandro
Di Giovanni, Giuseppe
Galati, Salvatore
Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals
title Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals
title_full Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals
title_fullStr Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals
title_full_unstemmed Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals
title_short Oscillatory Activity in the Cortex, Motor Thalamus and Nucleus Reticularis Thalami in Acute TTX and Chronic 6-OHDA Dopamine-Depleted Animals
title_sort oscillatory activity in the cortex, motor thalamus and nucleus reticularis thalami in acute ttx and chronic 6-ohda dopamine-depleted animals
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122290/
https://www.ncbi.nlm.nih.gov/pubmed/30210425
http://dx.doi.org/10.3389/fneur.2018.00663
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