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NGS-dataset of putative driver mutations associated with benign peritoneal strumosis
A rare case of benign peritoneal strumosis was screened for driver mutations in genes relevant to currently approved cancer therapies. Therefore, three formalin fixed paraffin embedded issue sections were screened with the GeneReader Actionable Insights NGS panel (Qiagen, Hilden, Germany) for the oc...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122335/ https://www.ncbi.nlm.nih.gov/pubmed/30186896 http://dx.doi.org/10.1016/j.dib.2018.08.006 |
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author | Brockmann, Michael Schildgen, Verena Schildgen, Oliver Lüsebrink, Jessica Pieper, Monika Gudima, Alexandru |
author_facet | Brockmann, Michael Schildgen, Verena Schildgen, Oliver Lüsebrink, Jessica Pieper, Monika Gudima, Alexandru |
author_sort | Brockmann, Michael |
collection | PubMed |
description | A rare case of benign peritoneal strumosis was screened for driver mutations in genes relevant to currently approved cancer therapies. Therefore, three formalin fixed paraffin embedded issue sections were screened with the GeneReader Actionable Insights NGS panel (Qiagen, Hilden, Germany) for the occurrence of driver mutations. Several mutations were identified in drug-targetable genes, such as ALK, EGFR, and BRAF. The majority of identified mutations were single nucleotide variant, but also a insertion/deletion mutation was identified. The presented dataset is the first NGS dataset available from a patient with benign peritoneal strumosis. |
format | Online Article Text |
id | pubmed-6122335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61223352018-09-05 NGS-dataset of putative driver mutations associated with benign peritoneal strumosis Brockmann, Michael Schildgen, Verena Schildgen, Oliver Lüsebrink, Jessica Pieper, Monika Gudima, Alexandru Data Brief Philosophy A rare case of benign peritoneal strumosis was screened for driver mutations in genes relevant to currently approved cancer therapies. Therefore, three formalin fixed paraffin embedded issue sections were screened with the GeneReader Actionable Insights NGS panel (Qiagen, Hilden, Germany) for the occurrence of driver mutations. Several mutations were identified in drug-targetable genes, such as ALK, EGFR, and BRAF. The majority of identified mutations were single nucleotide variant, but also a insertion/deletion mutation was identified. The presented dataset is the first NGS dataset available from a patient with benign peritoneal strumosis. Elsevier 2018-08-16 /pmc/articles/PMC6122335/ /pubmed/30186896 http://dx.doi.org/10.1016/j.dib.2018.08.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Philosophy Brockmann, Michael Schildgen, Verena Schildgen, Oliver Lüsebrink, Jessica Pieper, Monika Gudima, Alexandru NGS-dataset of putative driver mutations associated with benign peritoneal strumosis |
title | NGS-dataset of putative driver mutations associated with benign peritoneal strumosis |
title_full | NGS-dataset of putative driver mutations associated with benign peritoneal strumosis |
title_fullStr | NGS-dataset of putative driver mutations associated with benign peritoneal strumosis |
title_full_unstemmed | NGS-dataset of putative driver mutations associated with benign peritoneal strumosis |
title_short | NGS-dataset of putative driver mutations associated with benign peritoneal strumosis |
title_sort | ngs-dataset of putative driver mutations associated with benign peritoneal strumosis |
topic | Philosophy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122335/ https://www.ncbi.nlm.nih.gov/pubmed/30186896 http://dx.doi.org/10.1016/j.dib.2018.08.006 |
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