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NGS-dataset of putative driver mutations associated with benign peritoneal strumosis

A rare case of benign peritoneal strumosis was screened for driver mutations in genes relevant to currently approved cancer therapies. Therefore, three formalin fixed paraffin embedded issue sections were screened with the GeneReader Actionable Insights NGS panel (Qiagen, Hilden, Germany) for the oc...

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Autores principales: Brockmann, Michael, Schildgen, Verena, Schildgen, Oliver, Lüsebrink, Jessica, Pieper, Monika, Gudima, Alexandru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122335/
https://www.ncbi.nlm.nih.gov/pubmed/30186896
http://dx.doi.org/10.1016/j.dib.2018.08.006
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author Brockmann, Michael
Schildgen, Verena
Schildgen, Oliver
Lüsebrink, Jessica
Pieper, Monika
Gudima, Alexandru
author_facet Brockmann, Michael
Schildgen, Verena
Schildgen, Oliver
Lüsebrink, Jessica
Pieper, Monika
Gudima, Alexandru
author_sort Brockmann, Michael
collection PubMed
description A rare case of benign peritoneal strumosis was screened for driver mutations in genes relevant to currently approved cancer therapies. Therefore, three formalin fixed paraffin embedded issue sections were screened with the GeneReader Actionable Insights NGS panel (Qiagen, Hilden, Germany) for the occurrence of driver mutations. Several mutations were identified in drug-targetable genes, such as ALK, EGFR, and BRAF. The majority of identified mutations were single nucleotide variant, but also a insertion/deletion mutation was identified. The presented dataset is the first NGS dataset available from a patient with benign peritoneal strumosis.
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spelling pubmed-61223352018-09-05 NGS-dataset of putative driver mutations associated with benign peritoneal strumosis Brockmann, Michael Schildgen, Verena Schildgen, Oliver Lüsebrink, Jessica Pieper, Monika Gudima, Alexandru Data Brief Philosophy A rare case of benign peritoneal strumosis was screened for driver mutations in genes relevant to currently approved cancer therapies. Therefore, three formalin fixed paraffin embedded issue sections were screened with the GeneReader Actionable Insights NGS panel (Qiagen, Hilden, Germany) for the occurrence of driver mutations. Several mutations were identified in drug-targetable genes, such as ALK, EGFR, and BRAF. The majority of identified mutations were single nucleotide variant, but also a insertion/deletion mutation was identified. The presented dataset is the first NGS dataset available from a patient with benign peritoneal strumosis. Elsevier 2018-08-16 /pmc/articles/PMC6122335/ /pubmed/30186896 http://dx.doi.org/10.1016/j.dib.2018.08.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Philosophy
Brockmann, Michael
Schildgen, Verena
Schildgen, Oliver
Lüsebrink, Jessica
Pieper, Monika
Gudima, Alexandru
NGS-dataset of putative driver mutations associated with benign peritoneal strumosis
title NGS-dataset of putative driver mutations associated with benign peritoneal strumosis
title_full NGS-dataset of putative driver mutations associated with benign peritoneal strumosis
title_fullStr NGS-dataset of putative driver mutations associated with benign peritoneal strumosis
title_full_unstemmed NGS-dataset of putative driver mutations associated with benign peritoneal strumosis
title_short NGS-dataset of putative driver mutations associated with benign peritoneal strumosis
title_sort ngs-dataset of putative driver mutations associated with benign peritoneal strumosis
topic Philosophy
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122335/
https://www.ncbi.nlm.nih.gov/pubmed/30186896
http://dx.doi.org/10.1016/j.dib.2018.08.006
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