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Synthesis of 1,4-imino-L-lyxitols modified at C-5 and their evaluation as inhibitors of GH38 α-mannosidases
A synthetic approach to 1,4-imino-L-lyxitols with various modifications at the C-5 position is reported. These imino-L-lyxitol cores were used for the preparation of a series of N-(4-halobenzyl)polyhydroxypyrrolidines. An impact of the C-5 modification on the inhibition and selectivity against GH38...
Autores principales: | Bella, Maroš, Šesták, Sergej, Moncoľ, Ján, Koóš, Miroslav, Poláková, Monika |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Beilstein-Institut
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122390/ https://www.ncbi.nlm.nih.gov/pubmed/30202468 http://dx.doi.org/10.3762/bjoc.14.189 |
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