Flos Chrysanthemi Indici extract improves a high-sucrose diet-induced metabolic disorder in Drosophila

Flos Chrysanthemi Indici (CI) is a traditional medicinal plant used in the treatment of inflammatory diseases. However, the pharmacological role of CI in metabolic diseases, especially in diseases induced by insulin metabolism disorders, remains poorly understood. In the present study, Drosophila melanogaster (Drosophila) were fed with high-sugar diet (HSD) to induce a model similar to Type 2 diabetes (T2D) in order to determine whether CI extracts improve the metabolic disorder. It was demonstrated that the CI extracts could improve growth rate, body size, lifespan, reproductive capacity and fat storage, and CI especially improved the fat metabolism and cell size in S6k and Akt1 mutant flies. In conclusion, the present study provides novel evidence that CI may be an effective drug for the treatment of T2D.