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Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection

The present study aimed to discuss and compare the effects and expenses of different antibiotic regimens in the treatment of lower respiratory tract infection (LRTI). A retrospective analysis was performed on 200 patients diagnosed with LRTI and treated at the Department of Respiratory Medicine of D...

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Autores principales: Zhang, Lin, Liu, Benhong, Wang, Chunbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122520/
https://www.ncbi.nlm.nih.gov/pubmed/30210589
http://dx.doi.org/10.3892/etm.2018.6437
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author Zhang, Lin
Liu, Benhong
Wang, Chunbin
author_facet Zhang, Lin
Liu, Benhong
Wang, Chunbin
author_sort Zhang, Lin
collection PubMed
description The present study aimed to discuss and compare the effects and expenses of different antibiotic regimens in the treatment of lower respiratory tract infection (LRTI). A retrospective analysis was performed on 200 patients diagnosed with LRTI and treated at the Department of Respiratory Medicine of Dongying People's Hospital from February 2015 to May 2017. The patients were randomly divided into Group A, Group B, Group C and Group D, with 50 cases in each group, and were treated with ceftriaxone sodium, ceftizoxime sodium, levofloxacin and azithromycin, respectively. Venous blood of patients was collected. White blood cells (WBC) of venous blood were detected using a hematology analyzer and C-reactive protein (CRP) was tested with latex immunoturbidimetry. Moreover, therapeutic effects and drug costs of four different antibiotics were compared. No adverse reactions occurred to patients in the four groups during the treatment process. The value at each time point after treatment was significantly decreased compared with that at the previous time point before treatment within the group (P<0.01). The treatment expenses of patients in Group A, Group B and Group D were significantly increased compared with those in Group C (P<0.01), the treatment expenses of patients in Group B and Group D were significantly increased compared with those in Group A (P<0.01) and the treatment expenses of patients in Group D were significantly increased compared with those in Group B (P<0.01). Ceftriaxone sodium, ceftizoxime sodium, levofloxacin and azithromycin all have a good antimicrobial efficacy. The treatment condition of LRTI can be dynamically monitored by WBC and CRP which can accurately reflect the progression condition of patients' illness and the treatment effect. In economic terms, the treatment cost of levofloxacin is the lowest; thus, it is worthy of clinical popularization and application.
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spelling pubmed-61225202018-09-12 Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection Zhang, Lin Liu, Benhong Wang, Chunbin Exp Ther Med Articles The present study aimed to discuss and compare the effects and expenses of different antibiotic regimens in the treatment of lower respiratory tract infection (LRTI). A retrospective analysis was performed on 200 patients diagnosed with LRTI and treated at the Department of Respiratory Medicine of Dongying People's Hospital from February 2015 to May 2017. The patients were randomly divided into Group A, Group B, Group C and Group D, with 50 cases in each group, and were treated with ceftriaxone sodium, ceftizoxime sodium, levofloxacin and azithromycin, respectively. Venous blood of patients was collected. White blood cells (WBC) of venous blood were detected using a hematology analyzer and C-reactive protein (CRP) was tested with latex immunoturbidimetry. Moreover, therapeutic effects and drug costs of four different antibiotics were compared. No adverse reactions occurred to patients in the four groups during the treatment process. The value at each time point after treatment was significantly decreased compared with that at the previous time point before treatment within the group (P<0.01). The treatment expenses of patients in Group A, Group B and Group D were significantly increased compared with those in Group C (P<0.01), the treatment expenses of patients in Group B and Group D were significantly increased compared with those in Group A (P<0.01) and the treatment expenses of patients in Group D were significantly increased compared with those in Group B (P<0.01). Ceftriaxone sodium, ceftizoxime sodium, levofloxacin and azithromycin all have a good antimicrobial efficacy. The treatment condition of LRTI can be dynamically monitored by WBC and CRP which can accurately reflect the progression condition of patients' illness and the treatment effect. In economic terms, the treatment cost of levofloxacin is the lowest; thus, it is worthy of clinical popularization and application. D.A. Spandidos 2018-09 2018-07-11 /pmc/articles/PMC6122520/ /pubmed/30210589 http://dx.doi.org/10.3892/etm.2018.6437 Text en Copyright: © Zhang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Zhang, Lin
Liu, Benhong
Wang, Chunbin
Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection
title Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection
title_full Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection
title_fullStr Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection
title_full_unstemmed Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection
title_short Pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection
title_sort pharmaceutical analysis of different antibiotic regimens in the treatment of lower respiratory tract infection
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122520/
https://www.ncbi.nlm.nih.gov/pubmed/30210589
http://dx.doi.org/10.3892/etm.2018.6437
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