Automated nasopharyngeal carcinoma segmentation in magnetic resonance images by combination of convolutional neural networks and graph cut

Accurate and reliable segmentation of nasopharyngeal carcinoma (NPC) in medical images is an import task for clinical applications, including radiotherapy. However, NPC features large variations in lesion size and shape, as well as inhomogeneous intensities within the tumor and similar intensity to that of nearby tissues, making its segmentation a challenging task. The present study proposes a novel automated NPC segmentation method in magnetic resonance (MR) images by combining a deep convolutional neural network (CNN) model and a 3-dimensional (3D) graph cut-based method in a two-stage manner. First, a multi-view deep CNN-based segmentation method is performed. A voxel-wise initial segmentation is generated by integrating the inferential classification information of three trained single-view CNNs. Instead of directly using the CNN classification results to achieve a final segmentation, the proposed method uses a 3D graph cut-based method to refine the initial segmentation. Specifically, the probability response map obtained using the multi-view CNN method is utilized to calculate the region cost, which represents the likelihood of a voxel being assigned to the tumor or non-tumor. Structure information in 3D from the original MR images is used to calculate the boundary cost, which measures the difference between the two voxels in the 3D neighborhood. The proposed method was evaluated on T1-weighted images from 30 NPC patients using the leave-one-out method. The experimental results demonstrated that the proposed method is effective and accurate for NPC segmentation.