Chitosan-functionalized lipid-polymer hybrid nanoparticles for oral delivery of silymarin and enhanced lipid-lowering effect in NAFLD

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a chronic disease that causes excessive hepatic lipid accumulation. Reducing hepatic lipid deposition is a key issue in treatment and inhibition of NAFLD evolution. Silymarin is a potent hepatoprotective agent; however, it has low oral bioavai...

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Detalles Bibliográficos
Autores principales: Liang, Jun, Liu, Ying, Liu, Jinguang, Li, Zhe, Fan, Qiangyuan, Jiang, Zifei, Yan, Fei, Wang, Zhi, Huang, Peiwen, Feng, Nianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122632/
https://www.ncbi.nlm.nih.gov/pubmed/30176941
http://dx.doi.org/10.1186/s12951-018-0391-9

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