The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation

Slow inactivation in voltage-gated sodium channels (Na(V)s) directly regulates the excitability of neurons, cardiac myocytes, and skeletal muscles. Although Na(V) slow inactivation appears to be conserved across phylogenies—from bacteria to humans—the structural basis for this mechanism remains uncl...

Descripción completa

Detalles Bibliográficos
Autores principales: Chatterjee, Soumili, Vyas, Rajan, Chalamalasetti, Sreevatsa V., Sahu, Indra D., Clatot, Jérôme, Wan, Xiaoping, Lorigan, Gary A., Deschênes, Isabelle, Chakrapani, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122925/
https://www.ncbi.nlm.nih.gov/pubmed/30082431
http://dx.doi.org/10.1085/jgp.201812118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122925/
https://www.ncbi.nlm.nih.gov/pubmed/30082431
http://dx.doi.org/10.1085/jgp.201812118

Ejemplares similares