HNF1A is a novel oncogene that regulates human pancreatic cancer stem cell properties

The biological properties of pancreatic cancer stem cells (PCSCs) remain incompletely defined and the central regulators are unknown. By bioinformatic analysis of a human PCSC-enriched gene signature, we identified the transcription factor HNF1A as a putative central regulator of PCSC function. Leve...

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Detalles Bibliográficos
Autores principales: Abel, Ethan V, Goto, Masashi, Magnuson, Brian, Abraham, Saji, Ramanathan, Nikita, Hotaling, Emily, Alaniz, Anthony A, Kumar-Sinha, Chandan, Dziubinski, Michele L, Urs, Sumithra, Wang, Lidong, Shi, Jiaqi, Waghray, Meghna, Ljungman, Mats, Crawford, Howard C, Simeone, Diane M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122955/
https://www.ncbi.nlm.nih.gov/pubmed/30074477
http://dx.doi.org/10.7554/eLife.33947

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