Activated CARD11 accelerates germinal center kinetics, promoting mTORC1 and terminal differentiation

Activating mutations in the adapter protein CARD11 associated with diffuse large B cell lymphomas (DLBCLs) are predicted to arise during germinal center (GC) responses, leading to inappropriate activation of NF-κB signaling. Here, we modeled the B cell–intrinsic impact of the L251P activating mutati...

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Detalles Bibliográficos
Autores principales: Wray-Dutra, Michelle N., Chawla, Raghav, Thomas, Kerri R., Seymour, Brenda J., Arkatkar, Tanvi, Sommer, Karen M., Khim, Socheath, Trapnell, Cole, James, Richard G., Rawlings, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122963/
https://www.ncbi.nlm.nih.gov/pubmed/30127060
http://dx.doi.org/10.1084/jem.20180230

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