Cargando…

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease

There is considerable interest in harnessing innate immunity to treat Alzheimer’s disease (AD). Here, we explore whether a decoy receptor strategy using the ectodomain of select TLRs has therapeutic potential in AD. AAV-mediated expression of human TLR5 ectodomain (sTLR5) alone or fused to human IgG...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chakrabarty, Paramita, Li, Andrew, Ladd, Thomas B., Strickland, Michael R., Koller, Emily J., Burgess, Jeremy D., Funk, Cory C., Cruz, Pedro E., Allen, Mariet, Yaroshenko, Mariya, Wang, Xue, Younkin, Curtis, Reddy, Joseph, Lohrer, Benjamin, Mehrke, Leonie, Moore, Brenda D., Liu, Xuefei, Ceballos-Diaz, Carolina, Rosario, Awilda M., Medway, Christopher, Janus, Christopher, Li, Hong-Dong, Dickson, Dennis W., Giasson, Benoit I., Price, Nathan D., Younkin, Steven G., Ertekin-Taner, Nilüfer, Golde, Todd E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122970/ https://www.ncbi.nlm.nih.gov/pubmed/30158114 http://dx.doi.org/10.1084/jem.20180484

Ejemplares similares

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo
por: McFarland, Karen N, et al.
Publicado: (2021)

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains
por: Ma, Li, et al.
Publicado: (2016)

Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease
por: Li, Hong‐Dong, et al.
Publicado: (2021)

Late-onset Alzheimer disease risk variants mark brain regulatory loci
por: Allen, Mariet, et al.
Publicado: (2015)

Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice
por: Koller, Emily J., et al.
Publicado: (2017)

Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy
por: Allen, Mariet, et al.
Publicado: (2018)

An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform
por: Parikh, Ishita, et al.
Publicado: (2014)

Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy
por: Levites, Yona, et al.
Publicado: (2021)

IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
por: Strickland, Michael R., et al.
Publicado: (2020)

Author Correction: IL-10 based immunomodulation initiated at birth extends lifespan in a familial mouse model of amyotrophic lateral sclerosis
por: Strickland, Michael R., et al.
Publicado: (2021)

LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer’s Disease (LOAD)
por: Lincoln, Sarah, et al.
Publicado: (2013)

Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease
por: Golde, Todd E, et al.
Publicado: (2013)

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice
por: Prasad, Tuhina, et al.
Publicado: (2017)

Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer’s disease
por: Chung, Jaeyoon, et al.
Publicado: (2018)

Normal cognition in transgenic BRI2-Aβ mice
por: Kim, Jungsu, et al.
Publicado: (2013)

African American exome sequencing identifies potential risk variants at Alzheimer disease loci
por: N'Songo, Aurelie, et al.
Publicado: (2017)

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau
por: Croft, Cara L., et al.
Publicado: (2018)

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies
por: Dhillon, Jess-Karan S., et al.
Publicado: (2017)

Alzheimer’s disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions
por: Wang, Xue, et al.
Publicado: (2022)

Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases
por: Allen, Mariet, et al.
Publicado: (2016)

ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer’s disease
por: Medway, Christopher W, et al.
Publicado: (2014)

Il-10 signaling reduces survival in mouse models of synucleinopathy
por: Cockey, Samuel G., et al.
Publicado: (2021)

Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
por: Ibanez, Kristen R., et al.
Publicado: (2022)

Gene expression endophenotypes: a novel approach for gene discovery in Alzheimer's disease
por: Ertekin-Taner, Nilüfer
Publicado: (2011)

Genetics of Alzheimer disease in the pre- and post-GWAS era
por: Ertekin-Taner, Nilüfer
Publicado: (2010)

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau
por: Strang, Kevin H., et al.
Publicado: (2017)

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity
por: Sorrentino, Zachary A., et al.
Publicado: (2017)

Microglia-specific targeting by novel capsid-modified AAV6 vectors
por: Rosario, Awilda M, et al.
Publicado: (2016)

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains
por: Moore, Brenda D, et al.
Publicado: (2012)

Brain Expression Genome-Wide Association Study (eGWAS) Identifies Human Disease-Associated Variants
por: Zou, Fanggeng, et al.
Publicado: (2012)

Association of MAPT haplotypes with Alzheimer’s disease risk and MAPT brain gene expression levels
por: Allen, Mariet, et al.
Publicado: (2014)

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's Disease
por: Carrasquillo, Minerva M., et al.
Publicado: (2010)

Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease
por: Golde, Todd E, et al.
Publicado: (2013)

Student-Centered Microbioassay Laboratory Activity Utilizing Bioluminescent Bacteria
por: Younkin, Kerri, et al.
Publicado: (2018)

Tau-Mediated Dysregulation of Neuroplasticity and Glial Plasticity
por: Koller, Emily J., et al.
Publicado: (2020)

Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience
por: Ridge, Perry G., et al.
Publicado: (2017)

Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer’s disease resilience
por: Ridge, Perry G., et al.
Publicado: (2018)

Differential cross-seeding properties of tau and α-synuclein in mouse models of tauopathy and synucleinopathy
por: Williams, Tosha, et al.
Publicado: (2020)

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
por: Smith, Ethan D., et al.
Publicado: (2023)

Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease
por: Simmons, Christopher R, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_8uo0a8l31j4a6hbc6cokkbobc7