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TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

The progression of tau pathology in Alzheimer’s disease follows a stereotyped pattern, and recent evidence suggests a role of synaptic connections in this process. Astrocytes are well positioned at the neuronal synapse to capture and degrade extracellular tau as it transits the synapse and hence cou...

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Detalles Bibliográficos
Autores principales:	Martini-Stoica, Heidi, Cole, Allysa L., Swartzlander, Daniel B., Chen, Fading, Wan, Ying-Wooi, Bajaj, Lakshya, Bader, David A., Lee, Virginia M.Y., Trojanowski, John Q., Liu, Zhandong, Sardiello, Marco, Zheng, Hui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122971/ https://www.ncbi.nlm.nih.gov/pubmed/30108137 http://dx.doi.org/10.1084/jem.20172158

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