Cargando…

Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome

Metabolic programs are crucial for regulatory T (T reg) cell stability and function, but the underlying mechanisms that regulate T reg cell metabolism are elusive. Here, we report that lysosomal TRAF3IP3 acts as a pivotal regulator in the maintenance of T reg cell metabolic fitness. T reg–specific d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Xiaoyan, Teng, Xiao-Lu, Wang, Feixiang, Zheng, Yuhan, Qu, Guojun, Zhou, Yan, Hu, Zhilin, Wu, Zhongqiu, Chang, Yuzhou, Chen, Lei, Li, Hua-Bing, Su, Bing, Lu, Liming, Liu, Zhiduo, Sun, Shao-Cong, Zou, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122976/ https://www.ncbi.nlm.nih.gov/pubmed/30115741 http://dx.doi.org/10.1084/jem.20180397

Ejemplares similares

SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
por: Yu, Xiaoyan, et al.
Publicado: (2018)

ZFP91 is required for the maintenance of regulatory T cell homeostasis and function
por: Wang, Aiting, et al.
Publicado: (2020)

T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi
por: Zou, Qiang, et al.
Publicado: (2015)

Targeting TRAF3IP2 inhibits angiogenesis in glioblastoma
por: Izadpanah, Amin, et al.
Publicado: (2022)

TRAF3IP3 promotes glioma progression through the ERK signaling pathway
por: Lin, Qi, et al.
Publicado: (2022)

TRAF3IP2, a novel therapeutic target in glioblastoma multiforme
por: Alt, Eckhard U., et al.
Publicado: (2018)

TRAF5 and TRAF3IP2 Gene Polymorphisms Are Associated with Behçet's Disease and Vogt-Koyanagi-Harada Syndrome: A Case-Control Study
por: Xiang, Qin, et al.
Publicado: (2014)

TRAF3IP3 Is Cleaved by EV71 3C Protease and Exhibits Antiviral Activity
por: Li, Hui, et al.
Publicado: (2022)

The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves’ disease in the Chinese population
por: Li, Wei, et al.
Publicado: (2022)

Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis
por: Hüffmeier, Ulrike, et al.
Publicado: (2010)

Identification of human mutations in TRAF3IP1 in patients with nephronophthisis and retinal degeneration
por: Becker-Heck, A, et al.
Publicado: (2015)

TRAF3 regulates the effector function of regulatory T cells and humoral immune responses
por: Chang, Jae-Hoon, et al.
Publicado: (2014)

Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk
por: Dębniak, T., et al.
Publicado: (2013)

TRAF3IP2–IL-17 Axis Strengthens the Gingival Defense against Pathogens
por: Zhang, J., et al.
Publicado: (2022)

Novel germline TRAF3IP3 mutation in a dyad with familial acute B lymphoblastic leukemia
por: Pommert, Lauren, et al.
Publicado: (2021)

TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis
por: Huang, Xiaoran, et al.
Publicado: (2023)

Knockdown of TRAF3IP2 suppresses the expression of VEGFA and the proliferation of keratinocytes and vascular endothelial cells
por: Song, Yali, et al.
Publicado: (2019)

5mC and H3K9me3 of TRAF3IP2 promoter region accelerates the progression of translocation renal cell carcinoma
por: Yang, Lei, et al.
Publicado: (2022)

IP(3) Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca(2+) to Lysosomes
por: Atakpa, Peace, et al.
Publicado: (2018)

TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination
por: Deng, Meng, et al.
Publicado: (2020)

Rapid Recycling of Ca(2+) between IP(3)-Sensitive Stores and Lysosomes
por: López Sanjurjo, Cristina I., et al.
Publicado: (2014)

Identification of low-frequency TRAF3IP2 coding variants in psoriatic arthritis patients and functional characterization
por: Böhm, Beate, et al.
Publicado: (2012)

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization
por: Bizet, Albane A., et al.
Publicado: (2015)

Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer
por: Alt, Eckhard U., et al.
Publicado: (2020)

Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
por: Xie, Xiaoping, et al.
Publicado: (2019)

Inducible LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex
por: Xu, Gang, et al.
Publicado: (2019)

Lyso-IP: Uncovering Pathogenic Mechanisms of Lysosomal Dysfunction
por: Chen, Chase, et al.
Publicado: (2022)

TRAF3: Guardian of T lymphocyte functions
por: Hornick, Emma L., et al.
Publicado: (2023)

The Roles of TRAF3 in Immune Responses
por: Lin, Mengjiao, et al.
Publicado: (2023)

MicroRNA-194 Inhibits Lipopolysaccharide-Induced Inflammatory Response in Nucleus Pulposus Cells of the Intervertebral Disc by Targeting TNF Receptor-Associated Factor 6 (TRAF6)
por: Kong, Lili, et al.
Publicado: (2018)

Up-regulation and Pre-activation of TRAF3 and TRAF5 in Inflammatory Bowel Disease
por: Shen, Jun, et al.
Publicado: (2013)

Osteoclastic miR-214 targets TRAF3 to contribute to osteolytic bone metastasis of breast cancer
por: Liu, Jin, et al.
Publicado: (2017)

Clustering of IP(3) receptors by IP(3) retunes their regulation by IP(3) and Ca(2+)
por: Taufiq-Ur-Rahman,, et al.
Publicado: (2009)

STAT4, TRAF3IP2, IL10, and HCP5 Polymorphisms in Sjögren's Syndrome: Association with Disease Susceptibility and Clinical Aspects
por: Colafrancesco, Serena, et al.
Publicado: (2019)

Overexpression of SNTG2, TRAF3IP2, and ITGA6 transcripts is associated with osteoporotic vertebral fracture in elderly women from community
por: Jales Neto, Levi H., et al.
Publicado: (2020)

Impact of TRAF3IP2, IL10 and HCP5 Genetic Polymorphisms in the Response to TNF-i Treatment in Patients with Psoriatic Arthritis
por: De Benedittis, Giada, et al.
Publicado: (2022)

TRAF6 directs FOXP3 localization and facilitates regulatory T‐cell function through K63‐linked ubiquitination
por: Ni, Xuhao, et al.
Publicado: (2019)

USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation
por: Lu, Chih-Hao, et al.
Publicado: (2018)

Rv3722c Promotes Mycobacterium tuberculosis Survival in Macrophages by Interacting With TRAF3
por: Lei, Yingying, et al.
Publicado: (2021)

Genetic Polymorphisms of IL-17F and TRAF3IP2 Could Be Predictive Factors of the Long-Term Effect of Infliximab against Crohn's Disease
por: Urabe, Shigetoshi, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1i519to7fj8ltpu7f5q4l67u2v