Cell cycle pacemaker keeps adhesion in step with division

Adherent cells round up before division but it is unclear how detachment is regulated by the cell cycle. In this issue, Jones et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201802088) find the kinase CDK1 maintains adhesion during interphase by phosphorylating integrin adhesome proteins, in...

Descripción completa

Detalles Bibliográficos
Autor principal: Zaidel-Bar, Ronen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122993/
https://www.ncbi.nlm.nih.gov/pubmed/30115667
http://dx.doi.org/10.1083/jcb.201808067
_version_ 1783352770984673280
author Zaidel-Bar, Ronen
author_facet Zaidel-Bar, Ronen
author_sort Zaidel-Bar, Ronen
collection PubMed
description Adherent cells round up before division but it is unclear how detachment is regulated by the cell cycle. In this issue, Jones et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201802088) find the kinase CDK1 maintains adhesion during interphase by phosphorylating integrin adhesome proteins, including the formin FMNL2, and loss of this function of CDK1 activity in G2 triggers adhesion disassembly.
format Online
Article
Text
id pubmed-6122993
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-61229932019-03-03 Cell cycle pacemaker keeps adhesion in step with division Zaidel-Bar, Ronen J Cell Biol Commentaries Adherent cells round up before division but it is unclear how detachment is regulated by the cell cycle. In this issue, Jones et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201802088) find the kinase CDK1 maintains adhesion during interphase by phosphorylating integrin adhesome proteins, including the formin FMNL2, and loss of this function of CDK1 activity in G2 triggers adhesion disassembly. Rockefeller University Press 2018-09-03 /pmc/articles/PMC6122993/ /pubmed/30115667 http://dx.doi.org/10.1083/jcb.201808067 Text en © 2018 Zaidel-Bar http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Zaidel-Bar, Ronen
Cell cycle pacemaker keeps adhesion in step with division
title Cell cycle pacemaker keeps adhesion in step with division
title_full Cell cycle pacemaker keeps adhesion in step with division
title_fullStr Cell cycle pacemaker keeps adhesion in step with division
title_full_unstemmed Cell cycle pacemaker keeps adhesion in step with division
title_short Cell cycle pacemaker keeps adhesion in step with division
title_sort cell cycle pacemaker keeps adhesion in step with division
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122993/
https://www.ncbi.nlm.nih.gov/pubmed/30115667
http://dx.doi.org/10.1083/jcb.201808067
work_keys_str_mv AT zaidelbarronen cellcyclepacemakerkeepsadhesioninstepwithdivision

Ejemplares similares