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p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity

ARHGAP35 encoding p190A RhoGAP is a cancer-associated gene with a mutation spectrum suggestive of a tumor-suppressor function. In this study, we demonstrate that loss of heterozygosity for ARHGAP35 occurs in human tumors. We sought to identify tumor-suppressor capacities for p190A RhoGAP (p190A) and...

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Detalles Bibliográficos
Autores principales:	Frank, Scott R., Köllmann, Clemens P., Luong, Phi, Galli, Giorgio G., Zou, Lihua, Bernards, André, Getz, Gad, Calogero, Raffaele A., Frödin, Morten, Hansen, Steen H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122998/ https://www.ncbi.nlm.nih.gov/pubmed/29934311 http://dx.doi.org/10.1083/jcb.201710058

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