Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43

Desmoplakin (DP) is an obligate component of desmosomes, intercellular adhesive junctions that maintain the integrity of the epidermis and myocardium. Mutations in DP can cause cardiac and cutaneous disease, including arrhythmogenic cardiomyopathy (ACM), an inherited disorder that frequently results...

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Detalles Bibliográficos
Autores principales: Kam, Chen Yuan, Dubash, Adi D., Magistrati, Elisa, Polo, Simona, Satchell, Karla J.F., Sheikh, Farah, Lampe, Paul D., Green, Kathleen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123000/
https://www.ncbi.nlm.nih.gov/pubmed/29959233
http://dx.doi.org/10.1083/jcb.201710161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123000/
https://www.ncbi.nlm.nih.gov/pubmed/29959233
http://dx.doi.org/10.1083/jcb.201710161

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