Cargando…

The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis

Hepatocellular cancer (HCC) is one of the major causes of cancer-related mortality. Genetic polymorphisms may affect the susceptibility and clinical outcomes of cancers. We aim to manifest the association of single nucleotide polymorphisms (SNPs) of lncRNA-H19 gene with the risk and prognosis of HCC...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Ming-li, Huang, Zhe, Wang, Qian, Chen, Huan-huan, Ma, Sai-nan, Wu, Rong, Cai, Wei-song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123070/
https://www.ncbi.nlm.nih.gov/pubmed/29511035
http://dx.doi.org/10.1042/BSR20171652
_version_ 1783352785197072384
author Yang, Ming-li
Huang, Zhe
Wang, Qian
Chen, Huan-huan
Ma, Sai-nan
Wu, Rong
Cai, Wei-song
author_facet Yang, Ming-li
Huang, Zhe
Wang, Qian
Chen, Huan-huan
Ma, Sai-nan
Wu, Rong
Cai, Wei-song
author_sort Yang, Ming-li
collection PubMed
description Hepatocellular cancer (HCC) is one of the major causes of cancer-related mortality. Genetic polymorphisms may affect the susceptibility and clinical outcomes of cancers. We aim to manifest the association of single nucleotide polymorphisms (SNPs) of lncRNA-H19 gene with the risk and prognosis of HCC. A total of 944 samples composed of 472 HCC patients and 472 matched controls were included in the risk analysis and amongst them 350 HCC samples were investigated in the prognosis analysis. KASP method was conducted for the SNP genotyping. The TT + CT genotype of rs2839698 was found to be associated with a 1.32-fold increased HCC risk (P=0.037, 95% confidence interval (CI) = 1.02–1.70). In the stratified analysis, rs2839698 (odds ratio (OR) = 1.57, P=0.007, 95% CI = 1.13–2.18) and rs3024270 (OR = 1.71, P=0.019, 95% CI = 1.09–2.68) were found to show more obvious increased HCC risk in the age ≤60 subgroup. And we found that rs2839698 showed an increased HCC risk in the ever smoking subgroup. But in the male subgroup of rs2735971, it showed a decreased HCC risk. Furthermore, haplotype analysis showed that rs2735971-rs2839698-rs3024270 G-T-C significantly increased the risk of HCC (OR = 1.23, 95% CI = 1.01–1.51, P=0.043). Multilogistic analysis revealed no significant results of the interaction effects of the SNPs and environment factors. And in our study, rs2839698 showed a significant poor prognosis in the ever smoking subgroup (hazard rate (HR) = 5.19, 95% CI = 1.12–24.07, P=0.035). lncRNA-H19 rs2839698 SNP has the potential to be predictors for HCC risk and prognosis.
format Online
Article
Text
id pubmed-6123070
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-61230702018-09-10 The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis Yang, Ming-li Huang, Zhe Wang, Qian Chen, Huan-huan Ma, Sai-nan Wu, Rong Cai, Wei-song Biosci Rep Research Articles Hepatocellular cancer (HCC) is one of the major causes of cancer-related mortality. Genetic polymorphisms may affect the susceptibility and clinical outcomes of cancers. We aim to manifest the association of single nucleotide polymorphisms (SNPs) of lncRNA-H19 gene with the risk and prognosis of HCC. A total of 944 samples composed of 472 HCC patients and 472 matched controls were included in the risk analysis and amongst them 350 HCC samples were investigated in the prognosis analysis. KASP method was conducted for the SNP genotyping. The TT + CT genotype of rs2839698 was found to be associated with a 1.32-fold increased HCC risk (P=0.037, 95% confidence interval (CI) = 1.02–1.70). In the stratified analysis, rs2839698 (odds ratio (OR) = 1.57, P=0.007, 95% CI = 1.13–2.18) and rs3024270 (OR = 1.71, P=0.019, 95% CI = 1.09–2.68) were found to show more obvious increased HCC risk in the age ≤60 subgroup. And we found that rs2839698 showed an increased HCC risk in the ever smoking subgroup. But in the male subgroup of rs2735971, it showed a decreased HCC risk. Furthermore, haplotype analysis showed that rs2735971-rs2839698-rs3024270 G-T-C significantly increased the risk of HCC (OR = 1.23, 95% CI = 1.01–1.51, P=0.043). Multilogistic analysis revealed no significant results of the interaction effects of the SNPs and environment factors. And in our study, rs2839698 showed a significant poor prognosis in the ever smoking subgroup (hazard rate (HR) = 5.19, 95% CI = 1.12–24.07, P=0.035). lncRNA-H19 rs2839698 SNP has the potential to be predictors for HCC risk and prognosis. Portland Press Ltd. 2018-09-05 /pmc/articles/PMC6123070/ /pubmed/29511035 http://dx.doi.org/10.1042/BSR20171652 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Yang, Ming-li
Huang, Zhe
Wang, Qian
Chen, Huan-huan
Ma, Sai-nan
Wu, Rong
Cai, Wei-song
The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis
title The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis
title_full The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis
title_fullStr The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis
title_full_unstemmed The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis
title_short The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis
title_sort association of polymorphisms in lncrna-h19 with hepatocellular cancer risk and prognosis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123070/
https://www.ncbi.nlm.nih.gov/pubmed/29511035
http://dx.doi.org/10.1042/BSR20171652
work_keys_str_mv AT yangmingli theassociationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT huangzhe theassociationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT wangqian theassociationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT chenhuanhuan theassociationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT masainan theassociationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT wurong theassociationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT caiweisong theassociationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT yangmingli associationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT huangzhe associationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT wangqian associationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT chenhuanhuan associationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT masainan associationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT wurong associationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis
AT caiweisong associationofpolymorphismsinlncrnah19withhepatocellularcancerriskandprognosis