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The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis
Hepatocellular cancer (HCC) is one of the major causes of cancer-related mortality. Genetic polymorphisms may affect the susceptibility and clinical outcomes of cancers. We aim to manifest the association of single nucleotide polymorphisms (SNPs) of lncRNA-H19 gene with the risk and prognosis of HCC...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123070/ https://www.ncbi.nlm.nih.gov/pubmed/29511035 http://dx.doi.org/10.1042/BSR20171652 |
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author | Yang, Ming-li Huang, Zhe Wang, Qian Chen, Huan-huan Ma, Sai-nan Wu, Rong Cai, Wei-song |
author_facet | Yang, Ming-li Huang, Zhe Wang, Qian Chen, Huan-huan Ma, Sai-nan Wu, Rong Cai, Wei-song |
author_sort | Yang, Ming-li |
collection | PubMed |
description | Hepatocellular cancer (HCC) is one of the major causes of cancer-related mortality. Genetic polymorphisms may affect the susceptibility and clinical outcomes of cancers. We aim to manifest the association of single nucleotide polymorphisms (SNPs) of lncRNA-H19 gene with the risk and prognosis of HCC. A total of 944 samples composed of 472 HCC patients and 472 matched controls were included in the risk analysis and amongst them 350 HCC samples were investigated in the prognosis analysis. KASP method was conducted for the SNP genotyping. The TT + CT genotype of rs2839698 was found to be associated with a 1.32-fold increased HCC risk (P=0.037, 95% confidence interval (CI) = 1.02–1.70). In the stratified analysis, rs2839698 (odds ratio (OR) = 1.57, P=0.007, 95% CI = 1.13–2.18) and rs3024270 (OR = 1.71, P=0.019, 95% CI = 1.09–2.68) were found to show more obvious increased HCC risk in the age ≤60 subgroup. And we found that rs2839698 showed an increased HCC risk in the ever smoking subgroup. But in the male subgroup of rs2735971, it showed a decreased HCC risk. Furthermore, haplotype analysis showed that rs2735971-rs2839698-rs3024270 G-T-C significantly increased the risk of HCC (OR = 1.23, 95% CI = 1.01–1.51, P=0.043). Multilogistic analysis revealed no significant results of the interaction effects of the SNPs and environment factors. And in our study, rs2839698 showed a significant poor prognosis in the ever smoking subgroup (hazard rate (HR) = 5.19, 95% CI = 1.12–24.07, P=0.035). lncRNA-H19 rs2839698 SNP has the potential to be predictors for HCC risk and prognosis. |
format | Online Article Text |
id | pubmed-6123070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61230702018-09-10 The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis Yang, Ming-li Huang, Zhe Wang, Qian Chen, Huan-huan Ma, Sai-nan Wu, Rong Cai, Wei-song Biosci Rep Research Articles Hepatocellular cancer (HCC) is one of the major causes of cancer-related mortality. Genetic polymorphisms may affect the susceptibility and clinical outcomes of cancers. We aim to manifest the association of single nucleotide polymorphisms (SNPs) of lncRNA-H19 gene with the risk and prognosis of HCC. A total of 944 samples composed of 472 HCC patients and 472 matched controls were included in the risk analysis and amongst them 350 HCC samples were investigated in the prognosis analysis. KASP method was conducted for the SNP genotyping. The TT + CT genotype of rs2839698 was found to be associated with a 1.32-fold increased HCC risk (P=0.037, 95% confidence interval (CI) = 1.02–1.70). In the stratified analysis, rs2839698 (odds ratio (OR) = 1.57, P=0.007, 95% CI = 1.13–2.18) and rs3024270 (OR = 1.71, P=0.019, 95% CI = 1.09–2.68) were found to show more obvious increased HCC risk in the age ≤60 subgroup. And we found that rs2839698 showed an increased HCC risk in the ever smoking subgroup. But in the male subgroup of rs2735971, it showed a decreased HCC risk. Furthermore, haplotype analysis showed that rs2735971-rs2839698-rs3024270 G-T-C significantly increased the risk of HCC (OR = 1.23, 95% CI = 1.01–1.51, P=0.043). Multilogistic analysis revealed no significant results of the interaction effects of the SNPs and environment factors. And in our study, rs2839698 showed a significant poor prognosis in the ever smoking subgroup (hazard rate (HR) = 5.19, 95% CI = 1.12–24.07, P=0.035). lncRNA-H19 rs2839698 SNP has the potential to be predictors for HCC risk and prognosis. Portland Press Ltd. 2018-09-05 /pmc/articles/PMC6123070/ /pubmed/29511035 http://dx.doi.org/10.1042/BSR20171652 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Articles Yang, Ming-li Huang, Zhe Wang, Qian Chen, Huan-huan Ma, Sai-nan Wu, Rong Cai, Wei-song The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis |
title | The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis |
title_full | The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis |
title_fullStr | The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis |
title_full_unstemmed | The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis |
title_short | The association of polymorphisms in lncRNA-H19 with hepatocellular cancer risk and prognosis |
title_sort | association of polymorphisms in lncrna-h19 with hepatocellular cancer risk and prognosis |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123070/ https://www.ncbi.nlm.nih.gov/pubmed/29511035 http://dx.doi.org/10.1042/BSR20171652 |
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