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Phosphorylation of the Amyloid-Beta Peptide Inhibits Zinc-Dependent Aggregation, Prevents Na,K-ATPase Inhibition, and Reduces Cerebral Plaque Deposition

The triggers of late-onset sporadic Alzheimer’s disease (AD) are still poorly understood. Impairment of protein phosphorylation with age is well-known; however, the role of the phosphorylation in β-amyloid peptide (Aβ) is not studied sufficiently. Zinc-induced oligomerization of Aβ represents a pote...

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Detalles Bibliográficos
Autores principales:	Barykin, Evgeny P., Petrushanko, Irina Y., Kozin, Sergey A., Telegin, Georgy B., Chernov, Alexander S., Lopina, Olga D., Radko, Sergey P., Mitkevich, Vladimir A., Makarov, Alexander A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123382/ https://www.ncbi.nlm.nih.gov/pubmed/30210292 http://dx.doi.org/10.3389/fnmol.2018.00302

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