Interrupted reprogramming of alveolar type II cells induces progenitor-like cells that ameliorate pulmonary fibrosis

We describe here an interrupted reprogramming strategy to generate “induced progenitor-like (iPL) cells” from alveolar epithelial type II (AEC-II) cells. A carefully defined period of transient expression of reprogramming factors (Oct4, Sox2, Klf4, and c-Myc (OSKM)) is able to rescue the limited in...

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Detalles Bibliográficos
Autores principales: Guo, Li, Karoubi, Golnaz, Duchesneau, Pascal, Aoki, Fabio Gava, Shutova, Maria V., Rogers, Ian, Nagy, Andras, Waddell, Thomas K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123410/
https://www.ncbi.nlm.nih.gov/pubmed/30210809
http://dx.doi.org/10.1038/s41536-018-0052-5

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