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Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment

Ankylosing spondylitis (AS) is associated with high cardiovascular morbidity and mortality. Recent studies indicate that microvascular dysfunction may underlie cardiovascular risk in AS. We hypothesized, that microvascular morphology and dysfunction is linked to AS activity and is modifiable by TNF-...

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Autores principales: Batko, Bogdan, Maga, Pawel, Urbanski, Karol, Ryszawa-Mrozek, Natalia, Schramm-Luc, Agata, Koziej, Mateusz, Mikolajczyk, Tomasz, McGinnigle, Eilidh, Czesnikiewicz-Guzik, Marta, Ceranowicz, Piotr, Guzik, Tomasz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123474/
https://www.ncbi.nlm.nih.gov/pubmed/30181568
http://dx.doi.org/10.1038/s41598-018-31550-y
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author Batko, Bogdan
Maga, Pawel
Urbanski, Karol
Ryszawa-Mrozek, Natalia
Schramm-Luc, Agata
Koziej, Mateusz
Mikolajczyk, Tomasz
McGinnigle, Eilidh
Czesnikiewicz-Guzik, Marta
Ceranowicz, Piotr
Guzik, Tomasz J.
author_facet Batko, Bogdan
Maga, Pawel
Urbanski, Karol
Ryszawa-Mrozek, Natalia
Schramm-Luc, Agata
Koziej, Mateusz
Mikolajczyk, Tomasz
McGinnigle, Eilidh
Czesnikiewicz-Guzik, Marta
Ceranowicz, Piotr
Guzik, Tomasz J.
author_sort Batko, Bogdan
collection PubMed
description Ankylosing spondylitis (AS) is associated with high cardiovascular morbidity and mortality. Recent studies indicate that microvascular dysfunction may underlie cardiovascular risk in AS. We hypothesized, that microvascular morphology and dysfunction is linked to AS activity and is modifiable by TNF-α inhibitor (TNFi) treatment. Functional Laser Doppler Flowmetry with post-occlusive reactive hyperemia, and structural nailfold capillaroscopy were performed in 54 patients with AS and 28 matched controls. Active AS was diagnosed based on BASDAI ≥ 4 (n = 37). Effects of 3-month TNFi on microcirculation in active AS were studied. AS was associated with prolonged time to peak hyperemia compared to healthy controls. High disease activity was associated with increased time to peak hyperemia and decreased peak hyperemia when compared to patients with inactive AS. In capillaroscopy, AS was associated with morphological abnormalities indicating increased neoangiogenesis and pericapillary edema compared to controls. Microvascular function improved following 3 months of TNFi in reference to basal flow as well as post-occlusive parameters. TNFi reduced pericapillary edema, while other parameters of capillary morphology remained unchanged. Microvascular dysfunction and capillary neovascular formation are associated with disease activity of AS. Anti-TNF-α treatment may restore microcirculation function and capillary edema but does not modify microvascular structural parameters.
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spelling pubmed-61234742018-09-10 Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment Batko, Bogdan Maga, Pawel Urbanski, Karol Ryszawa-Mrozek, Natalia Schramm-Luc, Agata Koziej, Mateusz Mikolajczyk, Tomasz McGinnigle, Eilidh Czesnikiewicz-Guzik, Marta Ceranowicz, Piotr Guzik, Tomasz J. Sci Rep Article Ankylosing spondylitis (AS) is associated with high cardiovascular morbidity and mortality. Recent studies indicate that microvascular dysfunction may underlie cardiovascular risk in AS. We hypothesized, that microvascular morphology and dysfunction is linked to AS activity and is modifiable by TNF-α inhibitor (TNFi) treatment. Functional Laser Doppler Flowmetry with post-occlusive reactive hyperemia, and structural nailfold capillaroscopy were performed in 54 patients with AS and 28 matched controls. Active AS was diagnosed based on BASDAI ≥ 4 (n = 37). Effects of 3-month TNFi on microcirculation in active AS were studied. AS was associated with prolonged time to peak hyperemia compared to healthy controls. High disease activity was associated with increased time to peak hyperemia and decreased peak hyperemia when compared to patients with inactive AS. In capillaroscopy, AS was associated with morphological abnormalities indicating increased neoangiogenesis and pericapillary edema compared to controls. Microvascular function improved following 3 months of TNFi in reference to basal flow as well as post-occlusive parameters. TNFi reduced pericapillary edema, while other parameters of capillary morphology remained unchanged. Microvascular dysfunction and capillary neovascular formation are associated with disease activity of AS. Anti-TNF-α treatment may restore microcirculation function and capillary edema but does not modify microvascular structural parameters. Nature Publishing Group UK 2018-09-04 /pmc/articles/PMC6123474/ /pubmed/30181568 http://dx.doi.org/10.1038/s41598-018-31550-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Batko, Bogdan
Maga, Pawel
Urbanski, Karol
Ryszawa-Mrozek, Natalia
Schramm-Luc, Agata
Koziej, Mateusz
Mikolajczyk, Tomasz
McGinnigle, Eilidh
Czesnikiewicz-Guzik, Marta
Ceranowicz, Piotr
Guzik, Tomasz J.
Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment
title Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment
title_full Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment
title_fullStr Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment
title_full_unstemmed Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment
title_short Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment
title_sort microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-tnf treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123474/
https://www.ncbi.nlm.nih.gov/pubmed/30181568
http://dx.doi.org/10.1038/s41598-018-31550-y
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