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Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells
The aim of this study was to investigate the anti-inflammatory activity of 8-oxo-9-octadecenoic acid (OOA) isolated from Undaria peterseniana by examining its ability to inhibit the lipopolysaccharide (LPS)-induced production of inflammatory mediators in RAW 264.7 macrophage cells. We found that OOA...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123615/ https://www.ncbi.nlm.nih.gov/pubmed/30190667 http://dx.doi.org/10.17179/excli2018-1422 |
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author | Kang, Min-Cheol Ham, Young-Min Heo, Soo-Jin Yoon, Seon-A Cho, Su-Hyeon Kwon, Seung-Hae Jeong, Myeong Seon Jeon, You-Jin Sanjeewa, KKA Yoon, Weon-Jong Kim, Kil-Nam |
author_facet | Kang, Min-Cheol Ham, Young-Min Heo, Soo-Jin Yoon, Seon-A Cho, Su-Hyeon Kwon, Seung-Hae Jeong, Myeong Seon Jeon, You-Jin Sanjeewa, KKA Yoon, Weon-Jong Kim, Kil-Nam |
author_sort | Kang, Min-Cheol |
collection | PubMed |
description | The aim of this study was to investigate the anti-inflammatory activity of 8-oxo-9-octadecenoic acid (OOA) isolated from Undaria peterseniana by examining its ability to inhibit the lipopolysaccharide (LPS)-induced production of inflammatory mediators in RAW 264.7 macrophage cells. We found that OOA significantly suppressed the LPS-induced production of nitric oxide (NO) and inflammatory cytokines. OOA downregulated the LPS-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins. With respect to proinflammatory signaling pathways, OOA inhibited LPS-induced mitogen-activated protein kinase signaling by inhibiting the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK). Moreover, OOA inhibited LPS-induced nuclear factor (NF)-κB signaling by reducing the phosphorylation of IκB-α and p50 proteins. These results indicate that OOA significantly reduces proinflammatory signaling, which results in reduced expression of cytokines and proinflammatory mediators. Taken together, these results suggest that OOA has potent anti-inflammatory effects and could be considered an effective anti-inflammatory agent. |
format | Online Article Text |
id | pubmed-6123615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-61236152018-09-06 Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells Kang, Min-Cheol Ham, Young-Min Heo, Soo-Jin Yoon, Seon-A Cho, Su-Hyeon Kwon, Seung-Hae Jeong, Myeong Seon Jeon, You-Jin Sanjeewa, KKA Yoon, Weon-Jong Kim, Kil-Nam EXCLI J Original Article The aim of this study was to investigate the anti-inflammatory activity of 8-oxo-9-octadecenoic acid (OOA) isolated from Undaria peterseniana by examining its ability to inhibit the lipopolysaccharide (LPS)-induced production of inflammatory mediators in RAW 264.7 macrophage cells. We found that OOA significantly suppressed the LPS-induced production of nitric oxide (NO) and inflammatory cytokines. OOA downregulated the LPS-induced expression of inducible nitric oxide synthase and cyclooxygenase-2 proteins. With respect to proinflammatory signaling pathways, OOA inhibited LPS-induced mitogen-activated protein kinase signaling by inhibiting the phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK). Moreover, OOA inhibited LPS-induced nuclear factor (NF)-κB signaling by reducing the phosphorylation of IκB-α and p50 proteins. These results indicate that OOA significantly reduces proinflammatory signaling, which results in reduced expression of cytokines and proinflammatory mediators. Taken together, these results suggest that OOA has potent anti-inflammatory effects and could be considered an effective anti-inflammatory agent. Leibniz Research Centre for Working Environment and Human Factors 2018-08-02 /pmc/articles/PMC6123615/ /pubmed/30190667 http://dx.doi.org/10.17179/excli2018-1422 Text en Copyright © 2018 Kang et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Original Article Kang, Min-Cheol Ham, Young-Min Heo, Soo-Jin Yoon, Seon-A Cho, Su-Hyeon Kwon, Seung-Hae Jeong, Myeong Seon Jeon, You-Jin Sanjeewa, KKA Yoon, Weon-Jong Kim, Kil-Nam Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells |
title | Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells |
title_full | Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells |
title_fullStr | Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells |
title_full_unstemmed | Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells |
title_short | Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from Undaria peterseniana in lipopolysaccharide-stimulated macrophage cells |
title_sort | anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated from undaria peterseniana in lipopolysaccharide-stimulated macrophage cells |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123615/ https://www.ncbi.nlm.nih.gov/pubmed/30190667 http://dx.doi.org/10.17179/excli2018-1422 |
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