Activated protein C reverses epigenetically sustained p66(Shc) expression in plaque-associated macrophages in diabetes

Impaired activated protein C (aPC) generation is associated with atherosclerosis and diabetes mellitus. Diabetes-associated atherosclerosis is characterized by the hyperglycaemic memory, e.g., failure of disease improvement despite attenuation of hyperglycaemia. Therapies reversing the hyperglycaemi...

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Detalles Bibliográficos
Autores principales: Shahzad, Khurrum, Gadi, Ihsan, Nazir, Sumra, Al-Dabet, Moh’d Mohanad, Kohli, Shrey, Bock, Fabian, Breitenstein, Lukas, Ranjan, Satish, Fuchs, Tina, Halloul, Zuhir, Nawroth, Peter. P., Pelicci, Pier Giuseppe, Braun-Dullaeus, Ruediger C., Camerer, Eric, Esmon, Charles T., Isermann, Berend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123684/
https://www.ncbi.nlm.nih.gov/pubmed/30271984
http://dx.doi.org/10.1038/s42003-018-0108-5

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