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Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica

Investigating environmental hazards than could affect appendicularians is of prime ecological interest because they are among the most abundant components of the mesozooplankton. This work shows that embryo development of the appendicularian Oikopleura dioica is compromised by diatom bloom-derived b...

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Autores principales: Torres-Águila, Nuria P., Martí-Solans, Josep, Ferrández-Roldán, Alfonso, Almazán, Alba, Roncalli, Vittoria, D’Aniello, Salvatore, Romano, Giovanna, Palumbo, Anna, Albalat, Ricard, Cañestro, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123688/
https://www.ncbi.nlm.nih.gov/pubmed/30272001
http://dx.doi.org/10.1038/s42003-018-0127-2
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author Torres-Águila, Nuria P.
Martí-Solans, Josep
Ferrández-Roldán, Alfonso
Almazán, Alba
Roncalli, Vittoria
D’Aniello, Salvatore
Romano, Giovanna
Palumbo, Anna
Albalat, Ricard
Cañestro, Cristian
author_facet Torres-Águila, Nuria P.
Martí-Solans, Josep
Ferrández-Roldán, Alfonso
Almazán, Alba
Roncalli, Vittoria
D’Aniello, Salvatore
Romano, Giovanna
Palumbo, Anna
Albalat, Ricard
Cañestro, Cristian
author_sort Torres-Águila, Nuria P.
collection PubMed
description Investigating environmental hazards than could affect appendicularians is of prime ecological interest because they are among the most abundant components of the mesozooplankton. This work shows that embryo development of the appendicularian Oikopleura dioica is compromised by diatom bloom-derived biotoxins, even at concentrations in the same range as those measured after blooms. Developmental gene expression analysis of biotoxin-treated embryos uncovers an aberrant golf ball-like phenotype affecting morphogenesis, midline convergence, and tail elongation. Biotoxins induce a rapid upregulation of defensome genes, and considerable delay and silencing of zygotic transcription of developmental genes. Upon a possible future intensification of blooms associated with ocean warming and acidification, our work puts an alert on the potential impact that an increase of biotoxins may have on marine food webs, and points to defensome genes as molecular biosensors that marine ecologists could use to monitor the genetic stress of natural populations exposed to microalgal blooms.
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spelling pubmed-61236882018-09-28 Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica Torres-Águila, Nuria P. Martí-Solans, Josep Ferrández-Roldán, Alfonso Almazán, Alba Roncalli, Vittoria D’Aniello, Salvatore Romano, Giovanna Palumbo, Anna Albalat, Ricard Cañestro, Cristian Commun Biol Article Investigating environmental hazards than could affect appendicularians is of prime ecological interest because they are among the most abundant components of the mesozooplankton. This work shows that embryo development of the appendicularian Oikopleura dioica is compromised by diatom bloom-derived biotoxins, even at concentrations in the same range as those measured after blooms. Developmental gene expression analysis of biotoxin-treated embryos uncovers an aberrant golf ball-like phenotype affecting morphogenesis, midline convergence, and tail elongation. Biotoxins induce a rapid upregulation of defensome genes, and considerable delay and silencing of zygotic transcription of developmental genes. Upon a possible future intensification of blooms associated with ocean warming and acidification, our work puts an alert on the potential impact that an increase of biotoxins may have on marine food webs, and points to defensome genes as molecular biosensors that marine ecologists could use to monitor the genetic stress of natural populations exposed to microalgal blooms. Nature Publishing Group UK 2018-08-24 /pmc/articles/PMC6123688/ /pubmed/30272001 http://dx.doi.org/10.1038/s42003-018-0127-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Torres-Águila, Nuria P.
Martí-Solans, Josep
Ferrández-Roldán, Alfonso
Almazán, Alba
Roncalli, Vittoria
D’Aniello, Salvatore
Romano, Giovanna
Palumbo, Anna
Albalat, Ricard
Cañestro, Cristian
Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica
title Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica
title_full Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica
title_fullStr Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica
title_full_unstemmed Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica
title_short Diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate Oikopleura dioica
title_sort diatom bloom-derived biotoxins cause aberrant development and gene expression in the appendicularian chordate oikopleura dioica
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123688/
https://www.ncbi.nlm.nih.gov/pubmed/30272001
http://dx.doi.org/10.1038/s42003-018-0127-2
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