Cargando…
Conformational signatures in β-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor
Discovery of biased ligands and receptor mutants allows characterization of G-protein- and β-arrestin-mediated signaling mechanisms of G-protein-coupled receptors (GPCRs). However, the structural mechanisms underlying biased agonism remain unclear for many GPCRs. We show that while Galanin induces t...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123711/ https://www.ncbi.nlm.nih.gov/pubmed/30272007 http://dx.doi.org/10.1038/s42003-018-0134-3 |