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Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory
Because of the intrinsic randomness of the evolutionary process, a mutant with a fitness advantage has some chance to be selected but no certainty. Any experiment that searches for advantageous mutants will lose many of them due to random drift. It is therefore of great interest to find population s...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123726/ https://www.ncbi.nlm.nih.gov/pubmed/30271952 http://dx.doi.org/10.1038/s42003-018-0078-7 |
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author | Pavlogiannis, Andreas Tkadlec, Josef Chatterjee, Krishnendu Nowak, Martin A. |
author_facet | Pavlogiannis, Andreas Tkadlec, Josef Chatterjee, Krishnendu Nowak, Martin A. |
author_sort | Pavlogiannis, Andreas |
collection | PubMed |
description | Because of the intrinsic randomness of the evolutionary process, a mutant with a fitness advantage has some chance to be selected but no certainty. Any experiment that searches for advantageous mutants will lose many of them due to random drift. It is therefore of great interest to find population structures that improve the odds of advantageous mutants. Such structures are called amplifiers of natural selection: they increase the probability that advantageous mutants are selected. Arbitrarily strong amplifiers guarantee the selection of advantageous mutants, even for very small fitness advantage. Despite intensive research over the past decade, arbitrarily strong amplifiers have remained rare. Here we show how to construct a large variety of them. Our amplifiers are so simple that they could be useful in biotechnology, when optimizing biological molecules, or as a diagnostic tool, when searching for faster dividing cells or viruses. They could also occur in natural population structures. |
format | Online Article Text |
id | pubmed-6123726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61237262018-09-28 Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory Pavlogiannis, Andreas Tkadlec, Josef Chatterjee, Krishnendu Nowak, Martin A. Commun Biol Article Because of the intrinsic randomness of the evolutionary process, a mutant with a fitness advantage has some chance to be selected but no certainty. Any experiment that searches for advantageous mutants will lose many of them due to random drift. It is therefore of great interest to find population structures that improve the odds of advantageous mutants. Such structures are called amplifiers of natural selection: they increase the probability that advantageous mutants are selected. Arbitrarily strong amplifiers guarantee the selection of advantageous mutants, even for very small fitness advantage. Despite intensive research over the past decade, arbitrarily strong amplifiers have remained rare. Here we show how to construct a large variety of them. Our amplifiers are so simple that they could be useful in biotechnology, when optimizing biological molecules, or as a diagnostic tool, when searching for faster dividing cells or viruses. They could also occur in natural population structures. Nature Publishing Group UK 2018-06-14 /pmc/articles/PMC6123726/ /pubmed/30271952 http://dx.doi.org/10.1038/s42003-018-0078-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pavlogiannis, Andreas Tkadlec, Josef Chatterjee, Krishnendu Nowak, Martin A. Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory |
title | Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory |
title_full | Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory |
title_fullStr | Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory |
title_full_unstemmed | Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory |
title_short | Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory |
title_sort | construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123726/ https://www.ncbi.nlm.nih.gov/pubmed/30271952 http://dx.doi.org/10.1038/s42003-018-0078-7 |
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