Cargando…

Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory

Because of the intrinsic randomness of the evolutionary process, a mutant with a fitness advantage has some chance to be selected but no certainty. Any experiment that searches for advantageous mutants will lose many of them due to random drift. It is therefore of great interest to find population s...

Descripción completa

Detalles Bibliográficos
Autores principales: Pavlogiannis, Andreas, Tkadlec, Josef, Chatterjee, Krishnendu, Nowak, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123726/
https://www.ncbi.nlm.nih.gov/pubmed/30271952
http://dx.doi.org/10.1038/s42003-018-0078-7
_version_ 1783352897958838272
author Pavlogiannis, Andreas
Tkadlec, Josef
Chatterjee, Krishnendu
Nowak, Martin A.
author_facet Pavlogiannis, Andreas
Tkadlec, Josef
Chatterjee, Krishnendu
Nowak, Martin A.
author_sort Pavlogiannis, Andreas
collection PubMed
description Because of the intrinsic randomness of the evolutionary process, a mutant with a fitness advantage has some chance to be selected but no certainty. Any experiment that searches for advantageous mutants will lose many of them due to random drift. It is therefore of great interest to find population structures that improve the odds of advantageous mutants. Such structures are called amplifiers of natural selection: they increase the probability that advantageous mutants are selected. Arbitrarily strong amplifiers guarantee the selection of advantageous mutants, even for very small fitness advantage. Despite intensive research over the past decade, arbitrarily strong amplifiers have remained rare. Here we show how to construct a large variety of them. Our amplifiers are so simple that they could be useful in biotechnology, when optimizing biological molecules, or as a diagnostic tool, when searching for faster dividing cells or viruses. They could also occur in natural population structures.
format Online
Article
Text
id pubmed-6123726
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61237262018-09-28 Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory Pavlogiannis, Andreas Tkadlec, Josef Chatterjee, Krishnendu Nowak, Martin A. Commun Biol Article Because of the intrinsic randomness of the evolutionary process, a mutant with a fitness advantage has some chance to be selected but no certainty. Any experiment that searches for advantageous mutants will lose many of them due to random drift. It is therefore of great interest to find population structures that improve the odds of advantageous mutants. Such structures are called amplifiers of natural selection: they increase the probability that advantageous mutants are selected. Arbitrarily strong amplifiers guarantee the selection of advantageous mutants, even for very small fitness advantage. Despite intensive research over the past decade, arbitrarily strong amplifiers have remained rare. Here we show how to construct a large variety of them. Our amplifiers are so simple that they could be useful in biotechnology, when optimizing biological molecules, or as a diagnostic tool, when searching for faster dividing cells or viruses. They could also occur in natural population structures. Nature Publishing Group UK 2018-06-14 /pmc/articles/PMC6123726/ /pubmed/30271952 http://dx.doi.org/10.1038/s42003-018-0078-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Pavlogiannis, Andreas
Tkadlec, Josef
Chatterjee, Krishnendu
Nowak, Martin A.
Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory
title Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory
title_full Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory
title_fullStr Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory
title_full_unstemmed Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory
title_short Construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory
title_sort construction of arbitrarily strong amplifiers of natural selection using evolutionary graph theory
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123726/
https://www.ncbi.nlm.nih.gov/pubmed/30271952
http://dx.doi.org/10.1038/s42003-018-0078-7
work_keys_str_mv AT pavlogiannisandreas constructionofarbitrarilystrongamplifiersofnaturalselectionusingevolutionarygraphtheory
AT tkadlecjosef constructionofarbitrarilystrongamplifiersofnaturalselectionusingevolutionarygraphtheory
AT chatterjeekrishnendu constructionofarbitrarilystrongamplifiersofnaturalselectionusingevolutionarygraphtheory
AT nowakmartina constructionofarbitrarilystrongamplifiersofnaturalselectionusingevolutionarygraphtheory