Cargando…

Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions

The quality control testing of chemical degradations in the bio-pharmaceutical industry is currently under controversial debate. Here we have systematically applied in vitro and in vivo stress conditions to investigate the influence of protein degradation on structure-function. Extensive purificatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schmid, Ingrid, Bonnington, Lea, Gerl, Monika, Bomans, Katrin, Thaller, Anna Louisa, Wagner, Katharina, Schlothauer, Tilman, Falkenstein, Roberto, Zimmermann, Boris, Kopitz, Jürgen, Hasmann, Max, Bauss, Frieder, Haberger, Markus, Reusch, Dietmar, Bulau, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123738/ https://www.ncbi.nlm.nih.gov/pubmed/30271914 http://dx.doi.org/10.1038/s42003-018-0032-8

Ejemplares similares

Functional assessment of antibody oxidation by native mass spectrometry
por: Haberger, Markus, et al.
Publicado: (2015)

Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 2: Mass spectrometric methods
por: Reusch, Dietmar, et al.
Publicado: (2015)

Simultaneous Assessment of Asp Isomerization and Asn Deamidation in Recombinant Antibodies by LC-MS following Incubation at Elevated Temperatures
por: Diepold, Katharina, et al.
Publicado: (2012)

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes
por: Haberger, Markus, et al.
Publicado: (2014)

The Impact of Immunoglobulin G1 Fc Sialylation on Backbone Amide H/D Exchange
por: Kuhne, Felix, et al.
Publicado: (2019)

Comparison of methods for the analysis of therapeutic immunoglobulin G Fc-glycosylation profiles—Part 1: Separation-based methods
por: Reusch, Dietmar, et al.
Publicado: (2014)

Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry
por: Haberger, Markus, et al.
Publicado: (2015)

In Vitro Glycoengineering of IgG1 and Its Effect on Fc Receptor Binding and ADCC Activity
por: Thomann, Marco, et al.
Publicado: (2015)

Affinity purification of erythropoietin from cell culture supernatant combined with MALDI-TOF-MS analysis of erythropoietin N-glycosylation
por: Falck, David, et al.
Publicado: (2017)

Affinity Capillary Electrophoresis–Mass Spectrometry as a Tool to Unravel Proteoform-Specific Antibody–Receptor Interactions
por: Gstöttner, Christoph, et al.
Publicado: (2021)

Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS
por: Hensel, Miriam, et al.
Publicado: (2011)

Comprehensive Multidimensional Liquid Chromatography–Mass Spectrometry for the Characterization of Charge Variants of a Bispecific Antibody
por: Grunert, Ingrid, et al.
Publicado: (2022)

Function-structure approach reveals novel insights on the interplay of Immunoglobulin G 1 proteoforms and Fc gamma receptor IIa allotypes
por: Lippold, Steffen, et al.
Publicado: (2023)

Affinity capillary electrophoresis – mass spectrometry permits direct binding assessment of IgG and FcγRIIa in a glycoform-resolved manner
por: Gstöttner, Christoph, et al.
Publicado: (2022)

Identification and Monitoring of Host Cell Proteins by Mass Spectrometry Combined with High Performance Immunochemistry Testing
por: Bomans, Katrin, et al.
Publicado: (2013)

Discrepancies between High-Resolution Native and Glycopeptide-Centric Mass Spectrometric Approaches: A Case Study into the Glycosylation of Erythropoietin Variants
por: Čaval, Tomislav, et al.
Publicado: (2021)

Identification of Hetero-aggregates in Antibody Co-formulations by Multi-dimensional Liquid Chromatography Coupled to Mass Spectrometry
por: Kuhne, Felix, et al.
Publicado: (2023)

Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability
por: Grunert, Ingrid, et al.
Publicado: (2022)

Pertuzumab Increases 17-AAG-Induced Degradation of ErbB2, and This Effect Is Further Increased by Combining Pertuzumab with Trastuzumab
por: Hughes, Juliana Bentes, et al.
Publicado: (2012)

Defining the molecular response to trastuzumab, pertuzumab and combination therapy in ovarian cancer
por: Sims, A H, et al.
Publicado: (2012)

Glycoform-resolved FcɣRIIIa affinity chromatography–mass spectrometry
por: Lippold, Steffen, et al.
Publicado: (2019)

Characterization of high-molecular weight by-products in the production of a trivalent bispecific 2+1 heterodimeric antibody
por: Cramer, Dario A. T., et al.
Publicado: (2023)

Ibandronate: the first once-monthly oral bisphosphonate for treatment of postmenopausal osteoporosis
por: Bauss, Frieder, et al.
Publicado: (2006)

RDS: the radio data system
por: Kopitz, Dietmar, et al.
Publicado: (1999)

Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography–mass spectrometry
por: Lippold, Steffen, et al.
Publicado: (2021)

Review on Excess Noise Measurements of Resistors
por: Walter, Daniela, et al.
Publicado: (2023)

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier
por: Villaseñor, Roberto, et al.
Publicado: (2016)

Antigen physiochemical properties allosterically effect the IgG Fc-region and Fc neonatal receptor affinity
por: Sun, Yue, et al.
Publicado: (2020)

Parameters Associated with the Required Drug Dose of Intravenous Immunoglobulin in Stable Chronic Inflammatory Demyelinating Polyradiculoneuropathy
por: Feyen, Ludger, et al.
Publicado: (2023)

Monitoring glycation levels of a bispecific monoclonal antibody at subunit level by ultrahigh-resolution MALDI FT-ICR mass spectrometry
por: Gstöttner, Christoph, et al.
Publicado: (2019)

Glycosylation of recombinant rabbit immunoglobulins influences protease susceptibility as shown by comprehensive mass spectrometric glycan analysis
por: Friligou, Irene, et al.
Publicado: (2021)

B cells defined by immunoglobulin isotypes
por: James, Louisa Katherine
Publicado: (2022)

Resistance to Trastuzumab
por: Vivekanandhan, Sneha, et al.
Publicado: (2022)

Trastuzumab-induced thrombocytopenia after eight cycles of trastuzumab treatment
por: Zhou, Qiong, et al.
Publicado: (2020)

Trastuzumab in advanced breast cancer – a decade of experience in Germany
por: Jackisch, Christian, et al.
Publicado: (2014)

Intravenous and subcutaneous formulations of trastuzumab, and trastuzumab biosimilars: implications for clinical practice
por: Waller, Cornelius F., et al.
Publicado: (2021)

Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants
por: Dashivets, Tetyana, et al.
Publicado: (2015)

Endogenous cell surface lectin in Dictyostelium: quantitation, elution by sugar, and elicitation by divalent immunoglobulin
Publicado: (1980)

Analysis of a Compartmental Model of Endogenous Immunoglobulin G Metabolism with Application to Multiple Myeloma
por: Kendrick, Felicity, et al.
Publicado: (2017)

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement()
por: Sethu, Swaminathan, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_flueectca77o3ebanq6f59bem6