Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis

Necroptotic signaling converges in the assembly of a cytosolic signaling platform, the necrosome, with the activation of its downstream effector, MLKL. RIPK1 and RIPK3, key components of the necrosome, act as signaling intermediates for the activation of MLKL. We report that RIPK3 and MLKL continuou...

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Detalles Bibliográficos
Autores principales: Weber, Kathrin, Roelandt, Ria, Bruggeman, Inge, Estornes, Yann, Vandenabeele, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123744/
https://www.ncbi.nlm.nih.gov/pubmed/30271893
http://dx.doi.org/10.1038/s42003-017-0007-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123744/
https://www.ncbi.nlm.nih.gov/pubmed/30271893
http://dx.doi.org/10.1038/s42003-017-0007-1

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