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Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis

Nanosurfaces have improved clinical osseointegration by increasing bone/implant contact. Neovascularization is considered an essential prerequisite to osteogenesis, but no previous reports to our knowledge have examined the effect of surface topography on the spatio-temporal pattern of neovasculariz...

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Autores principales: Khosravi, Niloufar, Maeda, Azusa, DaCosta, Ralph S., Davies, John E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123776/
https://www.ncbi.nlm.nih.gov/pubmed/30271953
http://dx.doi.org/10.1038/s42003-018-0074-y
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author Khosravi, Niloufar
Maeda, Azusa
DaCosta, Ralph S.
Davies, John E.
author_facet Khosravi, Niloufar
Maeda, Azusa
DaCosta, Ralph S.
Davies, John E.
author_sort Khosravi, Niloufar
collection PubMed
description Nanosurfaces have improved clinical osseointegration by increasing bone/implant contact. Neovascularization is considered an essential prerequisite to osteogenesis, but no previous reports to our knowledge have examined the effect of surface topography on the spatio-temporal pattern of neovascularization during peri-implant healing. We have developed a cranial window model to study peri-implant healing intravitally over clinically relevant time scales as a function of implant topography. Quantitative intravital confocal imaging reveals that changing the topography (but not chemical composition) of an implant profoundly affects the pattern of peri-implant neovascularization. New vessels develop proximal to the implant and the vascular network matures sooner in the presence of an implant nanosurface. Accelerated angiogenesis can lead to earlier osseointegration through the delivery of osteogenic precursors to, and direct formation of bone on, the implant surface. This study highlights a critical aspect of peri-implant healing, but also informs the biological rationale for the surface design of putative endosseous implant materials.
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spelling pubmed-61237762018-09-28 Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis Khosravi, Niloufar Maeda, Azusa DaCosta, Ralph S. Davies, John E. Commun Biol Article Nanosurfaces have improved clinical osseointegration by increasing bone/implant contact. Neovascularization is considered an essential prerequisite to osteogenesis, but no previous reports to our knowledge have examined the effect of surface topography on the spatio-temporal pattern of neovascularization during peri-implant healing. We have developed a cranial window model to study peri-implant healing intravitally over clinically relevant time scales as a function of implant topography. Quantitative intravital confocal imaging reveals that changing the topography (but not chemical composition) of an implant profoundly affects the pattern of peri-implant neovascularization. New vessels develop proximal to the implant and the vascular network matures sooner in the presence of an implant nanosurface. Accelerated angiogenesis can lead to earlier osseointegration through the delivery of osteogenic precursors to, and direct formation of bone on, the implant surface. This study highlights a critical aspect of peri-implant healing, but also informs the biological rationale for the surface design of putative endosseous implant materials. Nature Publishing Group UK 2018-06-18 /pmc/articles/PMC6123776/ /pubmed/30271953 http://dx.doi.org/10.1038/s42003-018-0074-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Khosravi, Niloufar
Maeda, Azusa
DaCosta, Ralph S.
Davies, John E.
Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis
title Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis
title_full Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis
title_fullStr Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis
title_full_unstemmed Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis
title_short Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis
title_sort nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123776/
https://www.ncbi.nlm.nih.gov/pubmed/30271953
http://dx.doi.org/10.1038/s42003-018-0074-y
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