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Binding modes of CYP106A2 redox partners determine differences in progesterone hydroxylation product patterns

Natural redox partners of bacterial cytochrome P450s (P450s) are mostly unknown. Therefore, substrate conversions are performed with heterologous redox partners; in the case of CYP106A2 from Bacillus megaterium ATCC 13368, bovine adrenodoxin (Adx) and adrenodoxin reductase (AdR). Our aim was to opti...

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Detalles Bibliográficos
Autores principales:	Sagadin, Tanja, Riehm, Jan L., Milhim, Mohammed, Hutter, Michael C., Bernhardt, Rita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123783/ https://www.ncbi.nlm.nih.gov/pubmed/30271979 http://dx.doi.org/10.1038/s42003-018-0104-9

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