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Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination

BACKGROUND: Visual landmarks are used by head direction (HD) cells to establish and help update the animal’s representation of head direction, for use in orientation and navigation. Two cortical regions that are connected to primary visual areas, postsubiculum (PoS) and retrosplenial cortex (RSC), p...

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Autores principales: Lozano, Yave Roberto, Page, Hector, Jacob, Pierre-Yves, Lomi, Eleonora, Street, James, Jeffery, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124005/
https://www.ncbi.nlm.nih.gov/pubmed/30246155
http://dx.doi.org/10.1177/2398212817721859
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author Lozano, Yave Roberto
Page, Hector
Jacob, Pierre-Yves
Lomi, Eleonora
Street, James
Jeffery, Kate
author_facet Lozano, Yave Roberto
Page, Hector
Jacob, Pierre-Yves
Lomi, Eleonora
Street, James
Jeffery, Kate
author_sort Lozano, Yave Roberto
collection PubMed
description BACKGROUND: Visual landmarks are used by head direction (HD) cells to establish and help update the animal’s representation of head direction, for use in orientation and navigation. Two cortical regions that are connected to primary visual areas, postsubiculum (PoS) and retrosplenial cortex (RSC), possess HD cells: we investigated whether they differ in how they process visual landmarks. METHODS: We compared PoS and RSC HD cell activity from tetrode-implanted rats exploring an arena in which correct HD orientation required discrimination of two opposing landmarks having high, moderate or low discriminability. RESULTS: RSC HD cells had higher firing rates than PoS HD cells and slightly lower modulation by angular head velocity, and anticipated actual head direction by ~48 ms, indicating that RSC spiking leads PoS spiking. Otherwise, we saw no differences in landmark processing, in that HD cells in both regions showed equal responsiveness to and discrimination of the cues, with cells in both regions having unipolar directional tuning curves and showing better discrimination of the highly discriminable cues. There was a small spatial component to the signal in some cells, consistent with their role in interacting with the place cell navigation system, and there was also slight modulation by running speed. Neither region showed theta modulation of HD cell spiking. CONCLUSIONS: That the cells can immediately respond to subtle differences in spatial landmarks is consistent with rapid processing of visual snapshots or scenes; similarities in PoS and RSC responding may be due either to similar computations being performed on the visual inputs, or to rapid sharing of information between these regions. More generally, this two-cue HD cell paradigm may be a useful method for testing rapid spontaneous visual discrimination capabilities in other experimental settings.
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spelling pubmed-61240052018-09-19 Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination Lozano, Yave Roberto Page, Hector Jacob, Pierre-Yves Lomi, Eleonora Street, James Jeffery, Kate Brain Neurosci Adv Original Article BACKGROUND: Visual landmarks are used by head direction (HD) cells to establish and help update the animal’s representation of head direction, for use in orientation and navigation. Two cortical regions that are connected to primary visual areas, postsubiculum (PoS) and retrosplenial cortex (RSC), possess HD cells: we investigated whether they differ in how they process visual landmarks. METHODS: We compared PoS and RSC HD cell activity from tetrode-implanted rats exploring an arena in which correct HD orientation required discrimination of two opposing landmarks having high, moderate or low discriminability. RESULTS: RSC HD cells had higher firing rates than PoS HD cells and slightly lower modulation by angular head velocity, and anticipated actual head direction by ~48 ms, indicating that RSC spiking leads PoS spiking. Otherwise, we saw no differences in landmark processing, in that HD cells in both regions showed equal responsiveness to and discrimination of the cues, with cells in both regions having unipolar directional tuning curves and showing better discrimination of the highly discriminable cues. There was a small spatial component to the signal in some cells, consistent with their role in interacting with the place cell navigation system, and there was also slight modulation by running speed. Neither region showed theta modulation of HD cell spiking. CONCLUSIONS: That the cells can immediately respond to subtle differences in spatial landmarks is consistent with rapid processing of visual snapshots or scenes; similarities in PoS and RSC responding may be due either to similar computations being performed on the visual inputs, or to rapid sharing of information between these regions. More generally, this two-cue HD cell paradigm may be a useful method for testing rapid spontaneous visual discrimination capabilities in other experimental settings. SAGE Publications 2017-09-15 /pmc/articles/PMC6124005/ /pubmed/30246155 http://dx.doi.org/10.1177/2398212817721859 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Lozano, Yave Roberto
Page, Hector
Jacob, Pierre-Yves
Lomi, Eleonora
Street, James
Jeffery, Kate
Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination
title Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination
title_full Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination
title_fullStr Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination
title_full_unstemmed Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination
title_short Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination
title_sort retrosplenial and postsubicular head direction cells compared during visual landmark discrimination
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124005/
https://www.ncbi.nlm.nih.gov/pubmed/30246155
http://dx.doi.org/10.1177/2398212817721859
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