Sclerostin Antibody Treatment Stimulates Bone Formation to Normalize Bone Mass in Male Down Syndrome Mice

Down syndrome (DS), characterized by trisomy of human chromosome 21, is associated with a variety of endocrine disorders as well as profound skeletal abnormalities. The low bone mass phenotype in DS is defined by low bone turnover due to decreased osteoclast and osteoblast activity, decreasing the u...

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Detalles Bibliográficos
Autores principales: Williams, Diarra K, Parham, Sean G, Schryver, Eric, Akel, Nisreen S, Shelton, R Shane, Webber, Jessica, Swain, Francis L, Schmidt, Jami, Suva, Larry J, Gaddy, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124205/
https://www.ncbi.nlm.nih.gov/pubmed/30283889
http://dx.doi.org/10.1002/jbm4.10025

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