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Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection

AIM: This study was performed to investigate serum procalcitonin (PCT) and albumin (Alb) as prognostic biomarkers in elderly patients at risk of bacterial infection. METHODS: Serum PCT was measured in 270 hospitalized patients (mean age, 77.4 years) with suspected bacterial infection. The PCT-negati...

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Autores principales: Higashikawa, Toshihiro, Okuro, Masashi, Ishigami, Keiichirou, Mae, Kunihiro, Sangen, Ryusho, Mizuno, Takurou, Usuda, Daisuke, Saito, Atushi, Kasamaki, Yuji, Fukuda, Akihiro, Saito, Hitoshi, Morimoto, Shigeto, Kanda, Tsugiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124269/
https://www.ncbi.nlm.nih.gov/pubmed/29658355
http://dx.doi.org/10.1177/0300060518766640
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author Higashikawa, Toshihiro
Okuro, Masashi
Ishigami, Keiichirou
Mae, Kunihiro
Sangen, Ryusho
Mizuno, Takurou
Usuda, Daisuke
Saito, Atushi
Kasamaki, Yuji
Fukuda, Akihiro
Saito, Hitoshi
Morimoto, Shigeto
Kanda, Tsugiyasu
author_facet Higashikawa, Toshihiro
Okuro, Masashi
Ishigami, Keiichirou
Mae, Kunihiro
Sangen, Ryusho
Mizuno, Takurou
Usuda, Daisuke
Saito, Atushi
Kasamaki, Yuji
Fukuda, Akihiro
Saito, Hitoshi
Morimoto, Shigeto
Kanda, Tsugiyasu
author_sort Higashikawa, Toshihiro
collection PubMed
description AIM: This study was performed to investigate serum procalcitonin (PCT) and albumin (Alb) as prognostic biomarkers in elderly patients at risk of bacterial infection. METHODS: Serum PCT was measured in 270 hospitalized patients (mean age, 77.4 years) with suspected bacterial infection. The PCT-negative (<0.5 ng/mL) and PCT-positive (≥0.5 ng/mL) groups comprised 155 and 115 patients, respectively. Logistic regression analysis was performed with various clinical laboratory test values as independent variables and PCT positivity/negativity as the dependent variable. RESULTS: C-reactive protein (CRP) was the only independent variable significantly associated with PCT positivity/negativity. In the survival analysis, the 30-day in-hospital death rate was significantly higher in the PCT-positive than -negative group. Within the Alb-positive group (>2.5 g/dL), no significant difference in survival was observed between the PCT-positive and -negative groups. However, within the Alb-negative group (≤2.5 g/dL), the survival rate was significantly lower in the PCT-positive than -negative group. PCT was strongly associated with CRP and Alb, and having both PCT positivity and Alb negativity was a prognostic factor for elderly people at risk of bacterial infection. CONCLUSIONS: Combined measurement of PCT with Alb is expected to be a valuable tool to assess prognosis in elderly people at risk of bacterial infection.
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spelling pubmed-61242692018-09-10 Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection Higashikawa, Toshihiro Okuro, Masashi Ishigami, Keiichirou Mae, Kunihiro Sangen, Ryusho Mizuno, Takurou Usuda, Daisuke Saito, Atushi Kasamaki, Yuji Fukuda, Akihiro Saito, Hitoshi Morimoto, Shigeto Kanda, Tsugiyasu J Int Med Res Clinical Research Reports AIM: This study was performed to investigate serum procalcitonin (PCT) and albumin (Alb) as prognostic biomarkers in elderly patients at risk of bacterial infection. METHODS: Serum PCT was measured in 270 hospitalized patients (mean age, 77.4 years) with suspected bacterial infection. The PCT-negative (<0.5 ng/mL) and PCT-positive (≥0.5 ng/mL) groups comprised 155 and 115 patients, respectively. Logistic regression analysis was performed with various clinical laboratory test values as independent variables and PCT positivity/negativity as the dependent variable. RESULTS: C-reactive protein (CRP) was the only independent variable significantly associated with PCT positivity/negativity. In the survival analysis, the 30-day in-hospital death rate was significantly higher in the PCT-positive than -negative group. Within the Alb-positive group (>2.5 g/dL), no significant difference in survival was observed between the PCT-positive and -negative groups. However, within the Alb-negative group (≤2.5 g/dL), the survival rate was significantly lower in the PCT-positive than -negative group. PCT was strongly associated with CRP and Alb, and having both PCT positivity and Alb negativity was a prognostic factor for elderly people at risk of bacterial infection. CONCLUSIONS: Combined measurement of PCT with Alb is expected to be a valuable tool to assess prognosis in elderly people at risk of bacterial infection. SAGE Publications 2018-04-16 2018-07 /pmc/articles/PMC6124269/ /pubmed/29658355 http://dx.doi.org/10.1177/0300060518766640 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Clinical Research Reports
Higashikawa, Toshihiro
Okuro, Masashi
Ishigami, Keiichirou
Mae, Kunihiro
Sangen, Ryusho
Mizuno, Takurou
Usuda, Daisuke
Saito, Atushi
Kasamaki, Yuji
Fukuda, Akihiro
Saito, Hitoshi
Morimoto, Shigeto
Kanda, Tsugiyasu
Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection
title Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection
title_full Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection
title_fullStr Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection
title_full_unstemmed Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection
title_short Procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection
title_sort procalcitonin and albumin as prognostic biomarkers in elderly patients with a risk of bacterial infection
topic Clinical Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124269/
https://www.ncbi.nlm.nih.gov/pubmed/29658355
http://dx.doi.org/10.1177/0300060518766640
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