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Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study
OBJECTIVE: The focus of this study was the association between the metabolic syndrome (MetSyn) and cardiorespiratory fitness (CRF) defined as maximal oxygen uptake (VO(2max)). Although previous research has shown a relationship between MetSyn and CRF, most studies are based on less objective measure...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124330/ https://www.ncbi.nlm.nih.gov/pubmed/30225445 http://dx.doi.org/10.1016/j.mayocpiqo.2018.03.001 |
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author | Kelley, Elizabeth Imboden, Mary T. Harber, Matthew P. Finch, Holmes Kaminsky, Leonard A. Whaley, Mitchell H. |
author_facet | Kelley, Elizabeth Imboden, Mary T. Harber, Matthew P. Finch, Holmes Kaminsky, Leonard A. Whaley, Mitchell H. |
author_sort | Kelley, Elizabeth |
collection | PubMed |
description | OBJECTIVE: The focus of this study was the association between the metabolic syndrome (MetSyn) and cardiorespiratory fitness (CRF) defined as maximal oxygen uptake (VO(2max)). Although previous research has shown a relationship between MetSyn and CRF, most studies are based on less objective measures of CRF and different cardiometabolic risk factor thresholds from earlier guidelines. PARTICIPANTS AND METHODS: The metabolic markers included in the present study were central obesity, elevated plasma triglycerides, elevated fasting high-density lipoprotein cholesterol, impaired fasting plasma glucose, hypertension, or pharmacologic treatment for diagnosed hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol, or diabetes. A cohort of 3636 adults (1629 women, 2007 men; mean ± SD age, 44.7±12.3 years) completed CRF and metabolic risk factor assessment between January 1, 1971, and November 1, 2016. The CRF was defined as a measured VO(2max) from a cardiopulmonary exercise test on a treadmill, with a respiratory exchange ratio value of 1.0 or more. RESULTS: Prevalence of MetSyn (≥3 factors) was 26% (n=953) in the cohort, with men having a greater likelihood for MetSyn compared with women (P<.001). The difference in VO(2max) between those individuals with MetSyn and those without was approximately 2.3 (2.0-2.5) metabolic equivalents. Logistic regression analyses showed a significant inverse and graded association between quartiles of CRF and MetSyn for the group overall (P<.001), with odds ratios (95% CI) using the lowest fitness group as the referent group of 0.67 (0.55-0.81), 0.41 (0.34-0.51), and 0.10 (0.07-0.14) for VO(2max) (P<.001). The sex-specific odds ratios were 0.25 (0.18-0.34), 0.05 (0.02-0.10), and 0.02 (0.01-0.09) for women and 0.43 (0.31-0.59), 0.19 (0.14-0.27), and 0.03 (0.02-0.05) for men (P<.001). CONCLUSION: These results with current risk factor thresholds and a large number of women demonstrate that low VO(2max) is associated with MetSyn. |
format | Online Article Text |
id | pubmed-6124330 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61243302018-09-17 Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study Kelley, Elizabeth Imboden, Mary T. Harber, Matthew P. Finch, Holmes Kaminsky, Leonard A. Whaley, Mitchell H. Mayo Clin Proc Innov Qual Outcomes Original Article OBJECTIVE: The focus of this study was the association between the metabolic syndrome (MetSyn) and cardiorespiratory fitness (CRF) defined as maximal oxygen uptake (VO(2max)). Although previous research has shown a relationship between MetSyn and CRF, most studies are based on less objective measures of CRF and different cardiometabolic risk factor thresholds from earlier guidelines. PARTICIPANTS AND METHODS: The metabolic markers included in the present study were central obesity, elevated plasma triglycerides, elevated fasting high-density lipoprotein cholesterol, impaired fasting plasma glucose, hypertension, or pharmacologic treatment for diagnosed hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol, or diabetes. A cohort of 3636 adults (1629 women, 2007 men; mean ± SD age, 44.7±12.3 years) completed CRF and metabolic risk factor assessment between January 1, 1971, and November 1, 2016. The CRF was defined as a measured VO(2max) from a cardiopulmonary exercise test on a treadmill, with a respiratory exchange ratio value of 1.0 or more. RESULTS: Prevalence of MetSyn (≥3 factors) was 26% (n=953) in the cohort, with men having a greater likelihood for MetSyn compared with women (P<.001). The difference in VO(2max) between those individuals with MetSyn and those without was approximately 2.3 (2.0-2.5) metabolic equivalents. Logistic regression analyses showed a significant inverse and graded association between quartiles of CRF and MetSyn for the group overall (P<.001), with odds ratios (95% CI) using the lowest fitness group as the referent group of 0.67 (0.55-0.81), 0.41 (0.34-0.51), and 0.10 (0.07-0.14) for VO(2max) (P<.001). The sex-specific odds ratios were 0.25 (0.18-0.34), 0.05 (0.02-0.10), and 0.02 (0.01-0.09) for women and 0.43 (0.31-0.59), 0.19 (0.14-0.27), and 0.03 (0.02-0.05) for men (P<.001). CONCLUSION: These results with current risk factor thresholds and a large number of women demonstrate that low VO(2max) is associated with MetSyn. Elsevier 2018-05-08 /pmc/articles/PMC6124330/ /pubmed/30225445 http://dx.doi.org/10.1016/j.mayocpiqo.2018.03.001 Text en © 2018 THE AUTHORS https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Kelley, Elizabeth Imboden, Mary T. Harber, Matthew P. Finch, Holmes Kaminsky, Leonard A. Whaley, Mitchell H. Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study |
title | Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study |
title_full | Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study |
title_fullStr | Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study |
title_full_unstemmed | Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study |
title_short | Cardiorespiratory Fitness Is Inversely Associated With Clustering of Metabolic Syndrome Risk Factors: The Ball State Adult Fitness Program Longitudinal Lifestyle Study |
title_sort | cardiorespiratory fitness is inversely associated with clustering of metabolic syndrome risk factors: the ball state adult fitness program longitudinal lifestyle study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124330/ https://www.ncbi.nlm.nih.gov/pubmed/30225445 http://dx.doi.org/10.1016/j.mayocpiqo.2018.03.001 |
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