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A three-generation study on the association of tobacco smoking with asthma
BACKGROUND: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124624/ https://www.ncbi.nlm.nih.gov/pubmed/29534228 http://dx.doi.org/10.1093/ije/dyy031 |
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author | Accordini, Simone Calciano, Lucia Johannessen, Ane Portas, Laura Benediktsdóttir, Bryndis Bertelsen, Randi Jacobsen Bråbäck, Lennart Carsin, Anne-Elie Dharmage, Shyamali C Dratva, Julia Forsberg, Bertil Gomez Real, Francisco Heinrich, Joachim Holloway, John W Holm, Mathias Janson, Christer Jögi, Rain Leynaert, Bénédicte Malinovschi, Andrei Marcon, Alessandro Martínez-Moratalla Rovira, Jesús Raherison, Chantal Sánchez-Ramos, José Luis Schlünssen, Vivi Bono, Roberto Corsico, Angelo G Demoly, Pascal Dorado Arenas, Sandra Nowak, Dennis Pin, Isabelle Weyler, Joost Jarvis, Deborah Svanes, Cecilie |
author_facet | Accordini, Simone Calciano, Lucia Johannessen, Ane Portas, Laura Benediktsdóttir, Bryndis Bertelsen, Randi Jacobsen Bråbäck, Lennart Carsin, Anne-Elie Dharmage, Shyamali C Dratva, Julia Forsberg, Bertil Gomez Real, Francisco Heinrich, Joachim Holloway, John W Holm, Mathias Janson, Christer Jögi, Rain Leynaert, Bénédicte Malinovschi, Andrei Marcon, Alessandro Martínez-Moratalla Rovira, Jesús Raherison, Chantal Sánchez-Ramos, José Luis Schlünssen, Vivi Bono, Roberto Corsico, Angelo G Demoly, Pascal Dorado Arenas, Sandra Nowak, Dennis Pin, Isabelle Weyler, Joost Jarvis, Deborah Svanes, Cecilie |
author_sort | Accordini, Simone |
collection | PubMed |
description | BACKGROUND: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. METHODS: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. RESULTS: Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55). CONCLUSIONS: Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception. FUNDING: European Union (Horizon 2020, GA-633212). |
format | Online Article Text |
id | pubmed-6124624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61246242018-09-10 A three-generation study on the association of tobacco smoking with asthma Accordini, Simone Calciano, Lucia Johannessen, Ane Portas, Laura Benediktsdóttir, Bryndis Bertelsen, Randi Jacobsen Bråbäck, Lennart Carsin, Anne-Elie Dharmage, Shyamali C Dratva, Julia Forsberg, Bertil Gomez Real, Francisco Heinrich, Joachim Holloway, John W Holm, Mathias Janson, Christer Jögi, Rain Leynaert, Bénédicte Malinovschi, Andrei Marcon, Alessandro Martínez-Moratalla Rovira, Jesús Raherison, Chantal Sánchez-Ramos, José Luis Schlünssen, Vivi Bono, Roberto Corsico, Angelo G Demoly, Pascal Dorado Arenas, Sandra Nowak, Dennis Pin, Isabelle Weyler, Joost Jarvis, Deborah Svanes, Cecilie Int J Epidemiol Tobacco BACKGROUND: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. METHODS: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. RESULTS: Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55). CONCLUSIONS: Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception. FUNDING: European Union (Horizon 2020, GA-633212). Oxford University Press 2018-08 2018-03-09 /pmc/articles/PMC6124624/ /pubmed/29534228 http://dx.doi.org/10.1093/ije/dyy031 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the International Epidemiological Association. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Tobacco Accordini, Simone Calciano, Lucia Johannessen, Ane Portas, Laura Benediktsdóttir, Bryndis Bertelsen, Randi Jacobsen Bråbäck, Lennart Carsin, Anne-Elie Dharmage, Shyamali C Dratva, Julia Forsberg, Bertil Gomez Real, Francisco Heinrich, Joachim Holloway, John W Holm, Mathias Janson, Christer Jögi, Rain Leynaert, Bénédicte Malinovschi, Andrei Marcon, Alessandro Martínez-Moratalla Rovira, Jesús Raherison, Chantal Sánchez-Ramos, José Luis Schlünssen, Vivi Bono, Roberto Corsico, Angelo G Demoly, Pascal Dorado Arenas, Sandra Nowak, Dennis Pin, Isabelle Weyler, Joost Jarvis, Deborah Svanes, Cecilie A three-generation study on the association of tobacco smoking with asthma |
title | A three-generation study on the association of tobacco smoking with asthma |
title_full | A three-generation study on the association of tobacco smoking with asthma |
title_fullStr | A three-generation study on the association of tobacco smoking with asthma |
title_full_unstemmed | A three-generation study on the association of tobacco smoking with asthma |
title_short | A three-generation study on the association of tobacco smoking with asthma |
title_sort | three-generation study on the association of tobacco smoking with asthma |
topic | Tobacco |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124624/ https://www.ncbi.nlm.nih.gov/pubmed/29534228 http://dx.doi.org/10.1093/ije/dyy031 |
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