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A three-generation study on the association of tobacco smoking with asthma

BACKGROUND: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic...

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Autores principales: Accordini, Simone, Calciano, Lucia, Johannessen, Ane, Portas, Laura, Benediktsdóttir, Bryndis, Bertelsen, Randi Jacobsen, Bråbäck, Lennart, Carsin, Anne-Elie, Dharmage, Shyamali C, Dratva, Julia, Forsberg, Bertil, Gomez Real, Francisco, Heinrich, Joachim, Holloway, John W, Holm, Mathias, Janson, Christer, Jögi, Rain, Leynaert, Bénédicte, Malinovschi, Andrei, Marcon, Alessandro, Martínez-Moratalla Rovira, Jesús, Raherison, Chantal, Sánchez-Ramos, José Luis, Schlünssen, Vivi, Bono, Roberto, Corsico, Angelo G, Demoly, Pascal, Dorado Arenas, Sandra, Nowak, Dennis, Pin, Isabelle, Weyler, Joost, Jarvis, Deborah, Svanes, Cecilie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124624/
https://www.ncbi.nlm.nih.gov/pubmed/29534228
http://dx.doi.org/10.1093/ije/dyy031
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author Accordini, Simone
Calciano, Lucia
Johannessen, Ane
Portas, Laura
Benediktsdóttir, Bryndis
Bertelsen, Randi Jacobsen
Bråbäck, Lennart
Carsin, Anne-Elie
Dharmage, Shyamali C
Dratva, Julia
Forsberg, Bertil
Gomez Real, Francisco
Heinrich, Joachim
Holloway, John W
Holm, Mathias
Janson, Christer
Jögi, Rain
Leynaert, Bénédicte
Malinovschi, Andrei
Marcon, Alessandro
Martínez-Moratalla Rovira, Jesús
Raherison, Chantal
Sánchez-Ramos, José Luis
Schlünssen, Vivi
Bono, Roberto
Corsico, Angelo G
Demoly, Pascal
Dorado Arenas, Sandra
Nowak, Dennis
Pin, Isabelle
Weyler, Joost
Jarvis, Deborah
Svanes, Cecilie
author_facet Accordini, Simone
Calciano, Lucia
Johannessen, Ane
Portas, Laura
Benediktsdóttir, Bryndis
Bertelsen, Randi Jacobsen
Bråbäck, Lennart
Carsin, Anne-Elie
Dharmage, Shyamali C
Dratva, Julia
Forsberg, Bertil
Gomez Real, Francisco
Heinrich, Joachim
Holloway, John W
Holm, Mathias
Janson, Christer
Jögi, Rain
Leynaert, Bénédicte
Malinovschi, Andrei
Marcon, Alessandro
Martínez-Moratalla Rovira, Jesús
Raherison, Chantal
Sánchez-Ramos, José Luis
Schlünssen, Vivi
Bono, Roberto
Corsico, Angelo G
Demoly, Pascal
Dorado Arenas, Sandra
Nowak, Dennis
Pin, Isabelle
Weyler, Joost
Jarvis, Deborah
Svanes, Cecilie
author_sort Accordini, Simone
collection PubMed
description BACKGROUND: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. METHODS: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. RESULTS: Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55). CONCLUSIONS: Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception. FUNDING: European Union (Horizon 2020, GA-633212).
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spelling pubmed-61246242018-09-10 A three-generation study on the association of tobacco smoking with asthma Accordini, Simone Calciano, Lucia Johannessen, Ane Portas, Laura Benediktsdóttir, Bryndis Bertelsen, Randi Jacobsen Bråbäck, Lennart Carsin, Anne-Elie Dharmage, Shyamali C Dratva, Julia Forsberg, Bertil Gomez Real, Francisco Heinrich, Joachim Holloway, John W Holm, Mathias Janson, Christer Jögi, Rain Leynaert, Bénédicte Malinovschi, Andrei Marcon, Alessandro Martínez-Moratalla Rovira, Jesús Raherison, Chantal Sánchez-Ramos, José Luis Schlünssen, Vivi Bono, Roberto Corsico, Angelo G Demoly, Pascal Dorado Arenas, Sandra Nowak, Dennis Pin, Isabelle Weyler, Joost Jarvis, Deborah Svanes, Cecilie Int J Epidemiol Tobacco BACKGROUND: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. METHODS: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. RESULTS: Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01–1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17–2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02–1.55). CONCLUSIONS: Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception. FUNDING: European Union (Horizon 2020, GA-633212). Oxford University Press 2018-08 2018-03-09 /pmc/articles/PMC6124624/ /pubmed/29534228 http://dx.doi.org/10.1093/ije/dyy031 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of the International Epidemiological Association. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Tobacco
Accordini, Simone
Calciano, Lucia
Johannessen, Ane
Portas, Laura
Benediktsdóttir, Bryndis
Bertelsen, Randi Jacobsen
Bråbäck, Lennart
Carsin, Anne-Elie
Dharmage, Shyamali C
Dratva, Julia
Forsberg, Bertil
Gomez Real, Francisco
Heinrich, Joachim
Holloway, John W
Holm, Mathias
Janson, Christer
Jögi, Rain
Leynaert, Bénédicte
Malinovschi, Andrei
Marcon, Alessandro
Martínez-Moratalla Rovira, Jesús
Raherison, Chantal
Sánchez-Ramos, José Luis
Schlünssen, Vivi
Bono, Roberto
Corsico, Angelo G
Demoly, Pascal
Dorado Arenas, Sandra
Nowak, Dennis
Pin, Isabelle
Weyler, Joost
Jarvis, Deborah
Svanes, Cecilie
A three-generation study on the association of tobacco smoking with asthma
title A three-generation study on the association of tobacco smoking with asthma
title_full A three-generation study on the association of tobacco smoking with asthma
title_fullStr A three-generation study on the association of tobacco smoking with asthma
title_full_unstemmed A three-generation study on the association of tobacco smoking with asthma
title_short A three-generation study on the association of tobacco smoking with asthma
title_sort three-generation study on the association of tobacco smoking with asthma
topic Tobacco
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124624/
https://www.ncbi.nlm.nih.gov/pubmed/29534228
http://dx.doi.org/10.1093/ije/dyy031
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