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Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study
OBJECTIVE: Alteration in glutamatergic neurotransmission and dopaminergic dysfunction has been implicated in both the initiation and expression of addiction related behaviors. This pilot study was aimed to investigate the serum levels of glutamate and dopamine in adults with internet gaming disorder...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean College of Neuropsychopharmacology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124868/ https://www.ncbi.nlm.nih.gov/pubmed/30121977 http://dx.doi.org/10.9758/cpn.2018.16.3.276 |
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author | Paik, Soo-Hyun Choi, Mi Ran Kwak, Su Min Bang, Sol Hee Kim, Dai-Jin |
author_facet | Paik, Soo-Hyun Choi, Mi Ran Kwak, Su Min Bang, Sol Hee Kim, Dai-Jin |
author_sort | Paik, Soo-Hyun |
collection | PubMed |
description | OBJECTIVE: Alteration in glutamatergic neurotransmission and dopaminergic dysfunction has been implicated in both the initiation and expression of addiction related behaviors. This pilot study was aimed to investigate the serum levels of glutamate and dopamine in adults with internet gaming disorder (IGD). METHODS: We measured serum levels of glutamate and dopamine in male participants with IGD (n=26) and age-matched healthy controls (n=25). Clinical interviews were performed to identify IGD and to rule out psychiatric comorbidities. Serum levels of glutamate and dopamine were examined by enzyme immunoassays using ELISA Kits. RESULTS: Serum levels of glutamate were lower among IGD than control (IGD: 24.184±12.303 μg/ml; control: 33.676±12.413μg/ml; t=2.742, p=0.008), while levels of dopamine did not differ between. Serum glutamate and dopamine levels did not correlate with gaming hours and exposure to game in the IGD group. But serum glutamate levels were positively correlated with the dopamine levels (r=0.360, p=0.013). CONCLUSION: Our results suggest that altered glutamatergic neurotransmission may contribute to the pathophysiology of IGD. |
format | Online Article Text |
id | pubmed-6124868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean College of Neuropsychopharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61248682018-09-10 Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study Paik, Soo-Hyun Choi, Mi Ran Kwak, Su Min Bang, Sol Hee Kim, Dai-Jin Clin Psychopharmacol Neurosci Original Article OBJECTIVE: Alteration in glutamatergic neurotransmission and dopaminergic dysfunction has been implicated in both the initiation and expression of addiction related behaviors. This pilot study was aimed to investigate the serum levels of glutamate and dopamine in adults with internet gaming disorder (IGD). METHODS: We measured serum levels of glutamate and dopamine in male participants with IGD (n=26) and age-matched healthy controls (n=25). Clinical interviews were performed to identify IGD and to rule out psychiatric comorbidities. Serum levels of glutamate and dopamine were examined by enzyme immunoassays using ELISA Kits. RESULTS: Serum levels of glutamate were lower among IGD than control (IGD: 24.184±12.303 μg/ml; control: 33.676±12.413μg/ml; t=2.742, p=0.008), while levels of dopamine did not differ between. Serum glutamate and dopamine levels did not correlate with gaming hours and exposure to game in the IGD group. But serum glutamate levels were positively correlated with the dopamine levels (r=0.360, p=0.013). CONCLUSION: Our results suggest that altered glutamatergic neurotransmission may contribute to the pathophysiology of IGD. Korean College of Neuropsychopharmacology 2018-08 2018-08-31 /pmc/articles/PMC6124868/ /pubmed/30121977 http://dx.doi.org/10.9758/cpn.2018.16.3.276 Text en Copyright © 2018, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Paik, Soo-Hyun Choi, Mi Ran Kwak, Su Min Bang, Sol Hee Kim, Dai-Jin Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study |
title | Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study |
title_full | Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study |
title_fullStr | Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study |
title_full_unstemmed | Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study |
title_short | Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study |
title_sort | decreased serum glutamate levels in male adults with internet gaming disorder: a pilot study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124868/ https://www.ncbi.nlm.nih.gov/pubmed/30121977 http://dx.doi.org/10.9758/cpn.2018.16.3.276 |
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