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Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants
OBJECTIVE: The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans. METHODS: Eleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg,...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean College of Neuropsychopharmacology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124878/ https://www.ncbi.nlm.nih.gov/pubmed/30121974 http://dx.doi.org/10.9758/cpn.2018.16.3.253 |
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author | Frase, Lukas Doerr, John Peter Feige, Bernd Rechenbach, Maria Fiebich, Bernd L. Riemann, Dieter Nissen, Christoph Voderholzer, Ulrich |
author_facet | Frase, Lukas Doerr, John Peter Feige, Bernd Rechenbach, Maria Fiebich, Bernd L. Riemann, Dieter Nissen, Christoph Voderholzer, Ulrich |
author_sort | Frase, Lukas |
collection | PubMed |
description | OBJECTIVE: The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans. METHODS: Eleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed. RESULTS: A repeated measures multivariate analysis of variance revealed a significant main effect for the factor condition (AMI, ESC, PLA). Subsequent univariate analyses demonstrated significant condition effects for ghrelin and cortisol. Post-hoc analyses demonstrated a significant reduction of ghrelin levels after AMI in comparison to PLA, and a significant reduction of cortisol levels after AMI in comparison to both ESC and PLA. Other contrasts did not reach statistical significance. CONCLUSION: Administration of a single dose of AMI, but not of ESC, leads to a significant reduction in morning serum ghrelin and cortisol levels. No effects on leptin and prolactin levels were observed. The differential impact of AMI and ESC on hormones might contribute to different adverse effect profiles of both substances. |
format | Online Article Text |
id | pubmed-6124878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean College of Neuropsychopharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61248782018-09-10 Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants Frase, Lukas Doerr, John Peter Feige, Bernd Rechenbach, Maria Fiebich, Bernd L. Riemann, Dieter Nissen, Christoph Voderholzer, Ulrich Clin Psychopharmacol Neurosci Original Article OBJECTIVE: The primary aim of this study was to further characterize the acute effects of amitriptyline (AMI) and escitalopram (ESC) on serum levels of ghrelin, leptin, cortisol and prolactin in healthy humans. METHODS: Eleven healthy male participants received a single dose of AMI 75 mg, ESC 10 mg, or placebo (PLA) at 9:00 PM in a double blind, randomized, controlled, repeated measures study separated by one week. Fasting morning serum levels (7:00 AM) of ghrelin, leptin, cortisol and prolactin were assessed. RESULTS: A repeated measures multivariate analysis of variance revealed a significant main effect for the factor condition (AMI, ESC, PLA). Subsequent univariate analyses demonstrated significant condition effects for ghrelin and cortisol. Post-hoc analyses demonstrated a significant reduction of ghrelin levels after AMI in comparison to PLA, and a significant reduction of cortisol levels after AMI in comparison to both ESC and PLA. Other contrasts did not reach statistical significance. CONCLUSION: Administration of a single dose of AMI, but not of ESC, leads to a significant reduction in morning serum ghrelin and cortisol levels. No effects on leptin and prolactin levels were observed. The differential impact of AMI and ESC on hormones might contribute to different adverse effect profiles of both substances. Korean College of Neuropsychopharmacology 2018-08 2018-08-31 /pmc/articles/PMC6124878/ /pubmed/30121974 http://dx.doi.org/10.9758/cpn.2018.16.3.253 Text en Copyright © 2018, Korean College of Neuropsychopharmacology This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Frase, Lukas Doerr, John Peter Feige, Bernd Rechenbach, Maria Fiebich, Bernd L. Riemann, Dieter Nissen, Christoph Voderholzer, Ulrich Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants |
title | Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants |
title_full | Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants |
title_fullStr | Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants |
title_full_unstemmed | Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants |
title_short | Different Endocrine Effects of an Evening Dose of Amitriptyline, Escitalopram, and Placebo in Healthy Participants |
title_sort | different endocrine effects of an evening dose of amitriptyline, escitalopram, and placebo in healthy participants |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124878/ https://www.ncbi.nlm.nih.gov/pubmed/30121974 http://dx.doi.org/10.9758/cpn.2018.16.3.253 |
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