Cargando…
Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial
OBJECTIVE: In frozen and thawed embryos, the zona pellucida (ZP) can be damaged due to hardening. Laser-assisted hatching (LAH) of embryos can increase the pregnancy rate. This study compared thinning and drilling of the ZP before frozen embryo transfer (FET). METHODS: Patients were randomly allocat...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Reproductive Medicine
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125152/ https://www.ncbi.nlm.nih.gov/pubmed/30202743 http://dx.doi.org/10.5653/cerm.2018.45.3.129 |
_version_ | 1783353120023117824 |
---|---|
author | Le, Minh Tam Nguyen, Thi Tam An Nguyen, Thi Thai Thanh Nguyen, Van Trung Le, Dinh Duong Nguyen, Vu Quoc Huy Cao, Ngoc Thanh Aints, Alar Salumets, Andres |
author_facet | Le, Minh Tam Nguyen, Thi Tam An Nguyen, Thi Thai Thanh Nguyen, Van Trung Le, Dinh Duong Nguyen, Vu Quoc Huy Cao, Ngoc Thanh Aints, Alar Salumets, Andres |
author_sort | Le, Minh Tam |
collection | PubMed |
description | OBJECTIVE: In frozen and thawed embryos, the zona pellucida (ZP) can be damaged due to hardening. Laser-assisted hatching (LAH) of embryos can increase the pregnancy rate. This study compared thinning and drilling of the ZP before frozen embryo transfer (FET). METHODS: Patients were randomly allocated into two groups for LAH using thinning or drilling on day 2 after thawing. Twenty-five percent of the ZP circumference and 50% of the ZP thickness was removed in the thinning group, and a hole 40 µm in diameter was made in the drilling group. RESULTS: A total of 171 in vitro fertilization/intracytoplasmic sperm injection FET cycles, including 85 cycles with drilling LAH and 86 cycles with thinning LAH, were carried out. The thinning group had a similar β-human chorionic gonadotropin-positive rate (38.4% vs. 29.4%), implantation rate (16.5% vs. 14.4%), clinical pregnancy rate (36.0% vs. 25.9%), miscarriage rate (5.8% vs. 2.4%), ongoing pregnancy rate (30.2% vs. 23.5%), and multiple pregnancy rate (7.0% vs. 10.6%) to the drilling LAH group. There were no significant differences in pregnancy outcomes between subgroups defined based on age (older or younger than 35 years) or ZP thickness (greater or less than 17 µm) according to the LAH method. CONCLUSION: The present study demonstrated that partial ZP thinning or drilling resulted in similar outcomes in implantation and pregnancy rates using thawed embryos, irrespective of women's age or ZP thickness. |
format | Online Article Text |
id | pubmed-6125152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Society for Reproductive Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-61251522018-09-10 Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial Le, Minh Tam Nguyen, Thi Tam An Nguyen, Thi Thai Thanh Nguyen, Van Trung Le, Dinh Duong Nguyen, Vu Quoc Huy Cao, Ngoc Thanh Aints, Alar Salumets, Andres Clin Exp Reprod Med Original Article OBJECTIVE: In frozen and thawed embryos, the zona pellucida (ZP) can be damaged due to hardening. Laser-assisted hatching (LAH) of embryos can increase the pregnancy rate. This study compared thinning and drilling of the ZP before frozen embryo transfer (FET). METHODS: Patients were randomly allocated into two groups for LAH using thinning or drilling on day 2 after thawing. Twenty-five percent of the ZP circumference and 50% of the ZP thickness was removed in the thinning group, and a hole 40 µm in diameter was made in the drilling group. RESULTS: A total of 171 in vitro fertilization/intracytoplasmic sperm injection FET cycles, including 85 cycles with drilling LAH and 86 cycles with thinning LAH, were carried out. The thinning group had a similar β-human chorionic gonadotropin-positive rate (38.4% vs. 29.4%), implantation rate (16.5% vs. 14.4%), clinical pregnancy rate (36.0% vs. 25.9%), miscarriage rate (5.8% vs. 2.4%), ongoing pregnancy rate (30.2% vs. 23.5%), and multiple pregnancy rate (7.0% vs. 10.6%) to the drilling LAH group. There were no significant differences in pregnancy outcomes between subgroups defined based on age (older or younger than 35 years) or ZP thickness (greater or less than 17 µm) according to the LAH method. CONCLUSION: The present study demonstrated that partial ZP thinning or drilling resulted in similar outcomes in implantation and pregnancy rates using thawed embryos, irrespective of women's age or ZP thickness. The Korean Society for Reproductive Medicine 2018-09 2018-09-03 /pmc/articles/PMC6125152/ /pubmed/30202743 http://dx.doi.org/10.5653/cerm.2018.45.3.129 Text en Copyright © 2018. The Korean Society for Reproductive Medicine http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Le, Minh Tam Nguyen, Thi Tam An Nguyen, Thi Thai Thanh Nguyen, Van Trung Le, Dinh Duong Nguyen, Vu Quoc Huy Cao, Ngoc Thanh Aints, Alar Salumets, Andres Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial |
title | Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial |
title_full | Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial |
title_fullStr | Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial |
title_full_unstemmed | Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial |
title_short | Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial |
title_sort | thinning and drilling laser-assisted hatching in thawed embryo transfer: a randomized controlled trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125152/ https://www.ncbi.nlm.nih.gov/pubmed/30202743 http://dx.doi.org/10.5653/cerm.2018.45.3.129 |
work_keys_str_mv | AT leminhtam thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial AT nguyenthitaman thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial AT nguyenthithaithanh thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial AT nguyenvantrung thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial AT ledinhduong thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial AT nguyenvuquochuy thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial AT caongocthanh thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial AT aintsalar thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial AT salumetsandres thinninganddrillinglaserassistedhatchinginthawedembryotransferarandomizedcontrolledtrial |