Lysyl oxidase (LOX) limits VSMC proliferation and neointimal thickening through its extracellular enzymatic activity

Lysyl oxidase (LOX) plays a critical role in extracellular matrix maturation and limits VSMC proliferation and vascular remodeling. We have investigated whether this anti-proliferative effect relies on the extracellular catalytically active LOX or on its biologically active propeptide (LOX-PP). High...

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Detalles Bibliográficos
Autores principales: Varona, Saray, Orriols, Mar, Galán, María, Guadall, Anna, Cañes, Laia, Aguiló, Silvia, Sirvent, Marc, Martínez-González, José, Rodríguez, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125287/
https://www.ncbi.nlm.nih.gov/pubmed/30185869
http://dx.doi.org/10.1038/s41598-018-31312-w

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