Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases

Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6. The biological functions of IGFBPs can be classified as IGFs-dependent actions and IGFs-independent eff...

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Detalles Bibliográficos
Autores principales: Ding, Huihua, Wu, Tianfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125368/
https://www.ncbi.nlm.nih.gov/pubmed/30214426
http://dx.doi.org/10.3389/fendo.2018.00499
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author Ding, Huihua
Wu, Tianfu
author_facet Ding, Huihua
Wu, Tianfu
author_sort Ding, Huihua
collection PubMed
description Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6. The biological functions of IGFBPs can be classified as IGFs-dependent actions and IGFs-independent effects. In this review, we will discuss the structure and function of various IGFBPs, particularly IGFBPs as potential emerging biomarkers and therapeutic targets in various autoimmune diseases, and the possible mechanisms by which IGFBPs act on the pathogenesis of autoimmune diseases.
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spelling pubmed-61253682018-09-13 Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases Ding, Huihua Wu, Tianfu Front Endocrinol (Lausanne) Endocrinology Insulin-like growth factor binding proteins (IGFBPs) are a family of proteins binding to Insulin-like growth factors (IGFs), generally including IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, and IGFBP6. The biological functions of IGFBPs can be classified as IGFs-dependent actions and IGFs-independent effects. In this review, we will discuss the structure and function of various IGFBPs, particularly IGFBPs as potential emerging biomarkers and therapeutic targets in various autoimmune diseases, and the possible mechanisms by which IGFBPs act on the pathogenesis of autoimmune diseases. Frontiers Media S.A. 2018-08-30 /pmc/articles/PMC6125368/ /pubmed/30214426 http://dx.doi.org/10.3389/fendo.2018.00499 Text en Copyright © 2018 Ding and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ding, Huihua
Wu, Tianfu
Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
title Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
title_full Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
title_fullStr Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
title_full_unstemmed Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
title_short Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases
title_sort insulin-like growth factor binding proteins in autoimmune diseases
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125368/
https://www.ncbi.nlm.nih.gov/pubmed/30214426
http://dx.doi.org/10.3389/fendo.2018.00499
work_keys_str_mv AT dinghuihua insulinlikegrowthfactorbindingproteinsinautoimmunediseases
AT wutianfu insulinlikegrowthfactorbindingproteinsinautoimmunediseases

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