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PD1-CD28 Fusion Protein Enables CD4+ T Cell Help for Adoptive T Cell Therapy in Models of Pancreatic Cancer and Non-hodgkin Lymphoma

Background: Interaction of the programmed death receptor 1 (PD-1) and its ligand, PD-L1, suppresses T cell activity and permits tumors to evade T cell-mediated immune surveillance. We have recently demonstrated that antigen-specific CD8+ T cells transduced with a PD1-CD28 fusion protein are protecte...

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Detalles Bibliográficos
Autores principales:	Rataj, Felicitas, Kraus, Fabian B. T., Chaloupka, Michael, Grassmann, Simon, Heise, Constanze, Cadilha, Bruno L., Duewell, Peter, Endres, Stefan, Kobold, Sebastian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125378/ https://www.ncbi.nlm.nih.gov/pubmed/30214445 http://dx.doi.org/10.3389/fimmu.2018.01955

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