RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation

RAS GTPases are frequently mutated in human cancer. H- and NRAS isoforms are distributed over both plasma-membrane and endomembranes, including the Golgi complex, but how this organizational context contributes to cellular transformation is unknown. Here we show that RAS at the Golgi is selectively...

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Detalles Bibliográficos
Autores principales: Casar, Berta, Badrock, Andrew P., Jiménez, Iñaki, Arozarena, Imanol, Colón-Bolea, Paula, Lorenzo-Martín, L. Francisco, Barinaga-Rementería, Irene, Barriuso, Jorge, Cappitelli, Vincenzo, Donoghue, Daniel J., Bustelo, Xosé R., Hurlstone, Adam, Crespo, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125387/
https://www.ncbi.nlm.nih.gov/pubmed/30185827
http://dx.doi.org/10.1038/s41467-018-05941-8

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